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A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional Sensor

Jeon HJ, Jeong S, Choi HS, Jang SH, Kim SH, Kim SH, Lee JM, Kim ES, Keum B, Jeen YT, Lee HS, Chun HJ, Chung JH, Kim SN

Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance...
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Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment

Mou D, Yu Q, Zhang J, Zhou J, Li X, Zhuang W, Yang X

BACKGROUND: Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the...
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Development of chitosan-catechol conjugates as mucoadhesive polymer: assessment of acute oral toxicity in mice

Kaur L, Raj R, Thakur AK, Singh I

Development of modified polymers is the focused area of research for developing stable, effective, sustainable and economical polymeric materials for developing different drug delivery systems. Modification of chitosan by catechol...
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Hydrogel Production Platform with Dynamic Movement UsingPhoto-Crosslinkable/Temperature Reversible Chitosan Polymerand Stereolithography 4D Printing Technology

Seo JW, Shin SR, Park YJ, Bae H

BACKGROUND: Three-dimensional (3D) printing using hydrogel has made great strides when it comes to mimicking 3Dartificial tissue in the medical field. However, most structures do not mimic the dynamic movement...
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Antibacterial activity and characterization of tissue conditioner containing silver-chitosan nanocomplex

Nam KY

The objective of this work was to verify the antimicrobial effect and the characteristics of the tissue conditioner containing silver-chitosan nanocomplex at in vitro level. Nanocomplex was synthesized by the...
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Chitosan-Hydroxyapatite Scaffold for Tissue Engineering in Experimental Lumbar Laminectomy and Posterolateral Spinal Fusion in Wistar Rats

Rodríguez-Vázquez M, Ramos-Zúñiga R

Study Design: Experimental study with an animal model. Purpose: To evaluate the role of a chitosan and hydroxyapatite composite for spinal fusion in a lumbar experimental model based on regenerative tissue...
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Characterization of tissue conditioner containing chitosan-doped silver nanoparticles

Nam KY, Lee CJ

Purpose: Development of a latent antimicrobial soft liner is strongly needed to overcome a possible inflammation related with its dimensional degrade or surface roughness. Modified tissue conditioner (TC) containing chitosan-doped...
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Surface characterization of calcium phosphate coating formed on chitosan and alkali-treaDted titanium metal

Park KH, Lee WY, Song HJ, Park YJ

The calcium phosphate coating on various pretreated metals was prepared by soaking in modified simulated body fluid (m-SBF) solution. The coating structure and its surface morphologies were determined by x-ray...
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Development of Macroporous Chitosan Scaffolds for Eyelid Tarsus Tissue Engineering

Sun MT, O'Connor A, Milne I, Biswas D, Casson R, Wood J, Selva D

BACKGROUND: Reconstruction of large eyelid defects remains challenging due to the lack of suitable eyelid tarsus tissue substitutes. We aimed to evaluate a novel bioengineered chitosan scaffold for use as...
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Comparison of hemostatic efficacy and cytotoxicity of three ferric subsulfate- and chitosan-based styptics in different formulations using a rat tail bleeding model

Byun JY, Lee S, Lee JI, Yoon HY

This study was conducted to compare the hemostatic efficacy of three ferric subsulfate- and chitosan-based styptics as a powder and a gel containing ferric subsulfate and chitosan (FSC-PO and FSC-G,...
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Chitosan Pad, Cellulose Membrane, or Gelatin Sponge for Peridural Bleeding: An Efficacy Study on a Lumbar Laminectomized Rat Model

Sae-Jung S, Apiwatanakul P

STUDY DESIGN: Experimental study in an animal model. PURPOSE: This study aims to evaluate the hemostatic properties of four common hemostatic materials including the chitosan clot pad, absorbable gelatin sponge, cellulose...
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Immunogenicity of the nanovaccine containing intimin recombinant protein in the BALB/c mice

Hosseini Z, Amani J, Baghbani Arani F, Nazarian S, Motamedi M, Shafighian F

PURPOSE: Escherichia coli O157:H7 is one of the most important pathogens which create hemorrhagic colitis and hemolytic uremic syndrome in human. It is one of the most prevalent causes of...
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Analysis of the shelf life of chitosan stored in different types of packaging, using colorimetry and dentin microhardness

Cruz-Filho AMd, Bordin AR, Souza-Flamini LE, Guedes DF, Saquy PC, Silva RG, Pécora JD

OBJECTIVES: Chitosan has been widely investigated and used. However, the literature does not refer to the shelf life of this solution. This study evaluated, through the colorimetric titration technique and...
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Effect of a Chitosan Gel on Hemostasis and Prevention of Adhesion After Endoscopic Sinus Surgery

Chung YJ, An SY, Yeon JY, Shim WS, Mo JH

OBJECTIVES: Postoperative bleeding and adhesion formation are the two most common complications after endoscopic sinus surgery (ESS). The former sometimes can be life threatening and the latter is the most...
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In Vitro Performance of Injectable Chitosan-Tripolyphosphate Scaffolds Combined with Platelet-Rich Plasma

Shimojo AA, Galdames S, Perez AG, Ito TH, Malheiros Luzo AC, Santana MH

This study aimed to evaluate the in vitro biological effectiveness of chitosan microparticles crosslinked with sodium tripolyphosphate (TPP) in combination with activated pure platelet-rich plasma (aP-PRP) as an injectable composite...
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Protective effect of dietary chitosan on cadmium accumulation in rats

Kim MY, Shon WJ, Park MN, Lee YS, Shin DM

BACKGROUND/OBJECTIVES: Cadmium is a toxic metal that is an occupational and environmental concern especially because of its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even...
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Chitosan/Graphene and Poly(D, L-Lactic-co-Glycolic Acid)/Graphene Nano-Composites for Nerve Tissue Engineering

Soltani S, Ebrahimian-Hosseinabadi M, Kharazi AZ

This study aimed at examining and comparing the fabrication process, electrical conductivity, and biological properties of Chitosan/Graphene membranes and poly(D, L-lactic-co-glycolic acid) (PLGA)/Graphene membranes. Nano-composite membranes were made using chitosan...
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Comparative Study of Poly(L-Lactic Acid) Scaffolds Coated with Chitosan Nanoparticles Prepared via Ultrasonication and Ionic Gelation Techniques

Salehi M, Naseri-Nosar M, Azami M, Nodooshan , Arish J

In this study, an attempt was made to develop bi-functional constructs serving both as scaffolds and potential delivery systems for application in neural tissue engineering. The constructs were prepared in...
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Chitosan-Poly(Vinyl Alcohol) Nanofibers by Free Surface Electrospinning for Tissue Engineering Applications

Agrawal P, Pramanik K

Deformities in tissues and organs can be treated by using tissue engineering approach offering the development of biologically functionalized scaffolds from a variety of polymer blends which mimic the extracellular...
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Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models Using Various Imaging Modalities

Lee TK, Kwon J, Na KS, Jeong HS, Hwang H, Oh PS, Kim DH, Jang KY, Lim ST, Sohn MH, Jeong HJ

PURPOSE: Embolization is mainly used to reduce the size of locally advanced tumors. In this study, selective arterial catheterization with chitosan micro-hydrogels (CMH) into the femoral artery was performed and...
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