J Korean Assoc Maxillofac Plast Reconstr Surg.  2010 Jan;32(1):9-15.

BONE REGENERATION WITH INJECTABLE MPEG-PCL DIBLOCK COPOLYMER AND BONE MARROW MESENCHYMAL STEM CELL

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University, Korea. omfs1109@korea.ac.kr

Abstract

AIM OF THE STUDY: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model.
MATERIALS AND METHODS
New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis.
RESULTS
The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer.
CONCLUSION
It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.

Keyword

Injectable scaffold; MPEG-PCL diblock copolymer; Bone tissue engineering; BMP-2; Osteoblasts

MeSH Terms

Animals
Bone and Bones
Bone Marrow
Bone Regeneration
Hydrogel
Hydrogels
Mesenchymal Stromal Cells
Osteoblasts
Osteogenesis
Polyesters
Polyethylene Glycols
Rats
Transplants
Hydrogel
Hydrogels
Polyesters
Polyethylene Glycols
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