J Korean Med Sci.  2014 Nov;29(Suppl 3):S170-S175. 10.3346/jkms.2014.29.S3.S170.

Injectable Tissue-Engineered Soft Tissue for Tissue Augmentation

• Rhee SM
• You HJ
• Han SK

• KMID: 2151410
• DOI: http://doi.org/10.3346/jkms.2014.29.S3.S170

Abstract

Soft tissue augmentation is a process of implanting tissues or materials to treat wrinkles or soft tissue defects in the body. Over the years, various materials have evolved to correct soft tissue defects, including a number of tissues and polymers. Autogenous dermis, autogenous fat, autogenous dermis-fat, allogenic dermis, synthetic implants, and fillers have been widely accepted for soft tissue augmentations. Tissue engineering technology has also been introduced and opened a new venue of opportunities in this field. In particular, a long-lasting filler consisting of hyaluronic acid filler and living human mesenchymal cells called "injectable tissue-engineered soft tissue" has been created and applied clinically, as this strategy has many advantages over conventional methods. Fibroblasts and adipose-derived stromal vascular fraction cells can be clinically used as injectable tissue-engineered soft tissue at present. In this review, information on the soft tissue augmentation method using the injectable tissue-engineered soft tissue is provided.

Keyword

Cell Therapy; Soft Tissue; Tissue Engineering

MeSH Terms

Adipocytes/transplantation
Adipose Tissue/cytology
Biocompatible Materials
Connective Tissue/*surgery
Dermatologic Surgical Procedures/*methods
Face
Fibroblasts/transplantation
Humans
Hyaluronic Acid/therapeutic use
Injections, Intradermal
Mesenchymal Stem Cell Transplantation/*methods
Mesenchymal Stromal Cells
Skin
Skin Aging
Tissue Engineering/*methods
Biocompatible Materials
Hyaluronic Acid

Figure

• 

  Fig. 1 Application methods for injectable tissue-engineered soft tissue using cultured fibroblasts. (A) Skin harvesting. (B) Hyaluronic (HA) filler (yellow arrow) and a cultured fibroblast pellet (black arrow). (C) Cultured fibroblasts are mixed with the HA filler. (D) The fibroblasts suspended in the HA filler are injected into the nasal dorsum.

• 

  Fig. 2 A 59-yr-old woman was treated with injectable tissue-engineered soft tissue using fibroblasts for augmentation rhinoplasty. (A) Preoperative view. (B) Immediate postoperative view. (C) Two weeks after the injection. (D-F) Six, 12, and 18 months after the injection.

• 

  Fig. 3 Profile views of the Fig. 2 case.

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  Fig. 4 Deep glabellar wrinkles (arrows) of a 43-yr-old man were corrected by injecting stromal vascular fraction (SVF) cells suspended in a hyaluronic (HA) filler. (A) Preoperative view. (B) One year after the injection. (C) Three years after the injection. (D-F) Three-quarter views.

• 

  Fig. 5 A 30-yr-old woman was treated with injectable tissue-engineered soft tissue using stromal vascular fraction (SVF) cells for augmentation rhinoplasty. (A) Preoperative view. (B) Six months after the injection. (C) One year after the injection. (D) Six years after the injection.

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