Tissue Eng Regen Med.
2016 Apr;13(2):111-125. 10.1007/s13770-016-9063-8.
Gene Therapy for Bone Tissue Engineering
- Affiliations
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- 1Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Korea.
- 2Department of Chemical Engineering, Institute of Chemical Technology, Mumbai, India.
- 3Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Korea. chocs@snu.ac.kr
- 4Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.
- KMID: 2360851
- DOI: http://doi.org/10.1007/s13770-016-9063-8
Abstract
- Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered by combining different vectors (viral or non-viral), scaffolds and delivery methodologies. Ex vivo & in vivo gene enhanced tissue engineering approaches have led to successful osteogenic differentiation and bone formation. In this article, we review recent advances of gene therapy-based bone tissue engineering discussing strengths and weaknesses of various strategies as well as general overview of gene therapy.
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