Effect of Naloxone on CBF, CMRO2, CMRG and Arterial pH in Experimental Cereral Ischemia

Lee, Chong Oh; Lee, Hoon Kap; Lee, Ki Chan; Chu, Jeong Wha

Abstract

Naloxone has been recently reported to be benefit in the treatment of CNS ischemia. To study the effect of naloxone in an experimental stroke model, we subjected 20 adult cats to middle cerebral artery clipping for 4 hours by a retro-orbital extradural approach. Cerebral blood flow(CBF), cerebral metabolic rate of oxygen(CMRO2), cerebral metabolic rate of glucose(CMRG) and arterial pH were studied at postoperative 1 hour, 1 days, and 2 day. 10 cats were treated with nalxone 0.4mg intravenously every 2 hours for postoperative 48 hours. 10 cats were treated in a similar fashion with physiological saline(control group). The results are as follows; 1) The naloxone treated group showed increased CBF at the postoperative 1 hour. But after the 24 hours, there was not a significant difference in 2 groups. 2) The naloxone treated group showed decreased CMRO2 throughout the period when compared with control group. 3) The naloxone treated group showed decreased CMRG throughout the period when compared with control group. 4) Metabolic acidosis was improved by naloxone at the postoperative 1 hour and 24 hour when compared with control group.