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Laryngopharyngeal Reflux Disease: Diagnosis and Treatment in 2021

Kang JW, Eun YG

Laryngopharyngeal reflux disease (LPRD) is an inflammatory condition of the upper aerodigestive tract mucosa induced by reflux content from stomach. Some of vocal cord diseases are associated with laryngopharyngeal reflux....
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Evaluations of Gastric Acid Pocket Using Novel Vertical 8-Channel pH Monitoring System and Effects of Acid Secretion Inhibitors

Sumi S, Ishimura N, Mikami H, Okimoto E, Tamagawa Y, Mishiro T, Kinoshita Y, Ishihara S

  • KMID: 2517531
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):370-376.
  • doi: 10.5056/jnm20115
Background/Aims The gastric acid pocket has an important role in gastroesophageal reflux disease development. In this study, we utilized a novel 8-channel pH monitoring system with sensor intervals of 1 cm...
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Root proximity of the anchoring miniscrews of orthodontic miniplates in the mandibular incisal area: Cone-beam computed tomographic analysis

Jeong DM, Oh SH, Choo H, Choi YS, Kim SH, Lee JS, Hwang EH

Objective: This outcome analysis study evaluated the actual positions of the orthodontic miniplate and miniplate anchoring screws (MPASs) and the risk factors affecting adjacent anatomic structures after miniplate placement in...
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Evaluation of cytotoxicity and inflammatory tissue response of mineral trioxide aggregates containing dicalcium phosphate dihydrate

Park HJ, Park HC, Son G, Kim Y, Wu L, Choi SH, Yang HC

The purpose of this study was to evaluate the effect of dicalcium phosphate dihydrate (DCPD) on the biocompatibility of mineral trioxide aggregate (MTA). DCPD was added to MTA (OrthoMTA) to...
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The Role of Combined Multichannel Intraluminal Impedance-pH Monitoring in Infants with Brief, Resolved, Unexplained Events

Pavić I, Navratil M, Bosanac M, Fureš JS, Jureković II, Hojsak I

Purpose: Data on the relationship between gastroesophageal reflux (GER) and brief resolved unexplained events (BRUE) in infants is scarce. The aim of this study was to identify the characteristics of...
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Clinical Efficacy of Hormonal and Nonhormonal Agents in the Treatment of Vulvovaginal Atrophy

Ilhan G, Aslan MM, Cevrioglu AS, Yıldırım M, Erkorkmaz U

Objectives: Symptomatic local treatment of vaginal atrophy (VA) in menopausal women includes hormonal and nonhormonal preparations. Some women may be reluctant to use vaginal estradiol preparations because of the concern...
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Simultaneous Evaluation of Laryngopharyngeal Reflux and Swallowing Function Using Hypopharyngeal Multichannel Intraluminal Impedance Measurements in Neurologically Impaired Patients

Masui D, Fukahori S, Hashizume N, Ishii S, Higashidate N, Sakamoto S, Tsuruhisa S, Nakahara H, Saikusa N, Tanaka Y, Yagi M

  • KMID: 2514677
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):198-204.
  • doi: 10.5056/jnm20125
Background/Aims This study aims to evaluate the presence of laryngopharyngeal reflux (LPR) and to investigate the use of hypopharyngeal baseline impedance (BI) for assessing swallowing dysfunction and gastroesophageal reflux disease (GERD)...
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Usefulness of Endoscopic Hill Grade in Evaluating Children Suspected of Having Gastroesophageal Reflux Disease

Yoo IH, Joo JY, Yang HR

  • KMID: 2514676
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):191-197.
  • doi: 10.5056/jnm20033
Background/Aims This study aim to evaluate the relationship between the Hill grade confirmed by esophagogastroduodenoscopy (EGD) and the degree of gastroesophageal reflux (GER) by 24-hour multichannel intraluminal impedance-pH monitoring (MII-pH) in...
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Characteristics of Symptomatic Belching in Patients With Belching Disorder and Patients Who Exhibit Gastroesophageal Reflux Disease With Belching

Jeong SO, Lee JS, Lee TH, Hong SJ, Cho YS, Park J, Jeon SR, Kim HG, Kim JO

  • KMID: 2514681
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):231-239.
  • doi: 10.5056/jnm20114
Background/Aims Belching disorder (BD) is clinically distinct from gastroesophageal reflux disease (GERD) with belching. Supragastric belching (SGB) is closely associated with reflux episodes. This study investigates belch characteristics in association with...
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Short-term Changes in Ocular Surface pH after 23-gauge Microincision Vitrectomy Surgery

Oh JH, Park SJ, Kang DJ, Kang YK, Shin JP, Park DH

Purpose: This study aimed to investigate changes in ocular surface pH after 23-gauge microincision vitrectomy surgery. Methods: This retrospective study included 42 patients who underwent 23-gauge microincision vitrectomy. Best-corrected visual acuity...
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Validation of Self-Reported Smartphone Usage Against Objectively-Measured Smartphone Usage in Hong Kong Chinese Adolescents and Young Adults

Lee PH, Tse ACY, Wu CST, Mak YW, Lee U

Objective This study evaluated the validity of self-reported smartphone usage data against objectively-measured smartphone usage data by directly tracking the activities in the participants’ smartphone among Chinese adolescents and young...
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Imaging Predictors of Survival in Patients with Single Small Hepatocellular Carcinoma Treated with Transarterial Chemoembolization

Park C, Kim JH, Kim PH, Kim SY, Gwon DI, Chu HH, Park M, Hur J, Kim JY, Kim DJ

Objective: Clinical outcomes of patients who undergo transarterial chemoembolization (TACE) for single small hepatocellular carcinoma (HCC) are not consistent, and may differ based on certain imaging findings. This retrospective study...
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Patients With Definite and Inconclusive Evidence of Reflux According to Lyon Consensus Display Similar Motility and Esophagogastric Junction Characteristics

Ribolsi M, Savarino E, Rogers B, Rengarajan A, Coletta MD, Ghisa M, Cicala M, Gyawali CP

  • KMID: 2521157
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):565-573.
  • doi: 10.5056/jnm20158
Background/Aims The role of esophageal high-resolution manometry (HRM) within Lyon consensus phenotypes, especially patients with inconclusive gastroesophageal reflux disease (GERD) evidence, has not been fully investigated. In this multicenter, observational study...
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Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory Non-erosive Reflux Disease

Wang Y, Ye B, Wang M, Lin L, Jiang L

  • KMID: 2521152
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):525-532.
  • doi: 10.5056/jnm20073
Background/Aims Esophageal mean nocturnal baseline impedance (MNBI) levels and post-reflux swallow-induced peristaltic wave (PSPW) index could increase the diagnostic value of 24-hour multichannel intraluminal impedance and pH monitoring in patients with...
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2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease

Jung HK, Tae CH, Song KH, Kang SJ, Park JK, Gong EJ, Shin JE, Lim HC, Lee SK, Jung DH, Choi YJ, Seo SI, Kim JS, Lee JM, Kim BJ, Kang SH, Park CH, Choi SC, Kwon JG, Park KS, Park MI, Lee TH, Kim SY, Cho YS, Lee HH, Jung KW, Kim DH, Moon HS, Miwa H, Chen CL, Gonlachanvit S, Ghoshal UC, Wu JCY, Siah KTH, Hou X, Oshima T, Choi MY, Lee KJ, TKSoNaM

  • KMID: 2521147
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):453-481.
  • doi: 10.5056/jnm21077
Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate into the esophagus or beyond, resulting in either troublesome symptoms or complications. GERD is heterogeneous in terms of...
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Acid Exposure Time > 6% Might Not Improve the Therapeutic Outcome in Chinese Gastroesophageal Reflux Disease Patients

Lin Y, Li Y, Liang M, Tan N, Zhang M, Chen S, Xiao Y

  • KMID: 2510062
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):55-62.
  • doi: 10.5056/jnm19219
Background/Aims There is less acid burden in Chinese gastroesophageal reflux disease (GERD) patients. However, the Lyon consensus proposed a higher threshold of acid exposure time (AET > 6%) for GERD. The...
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Endoscopic Prediction for Acid Reflux in Patients without Hiatus Hernia

Kim JY, Shin IS, Min YW, Kim K, Lee H, Min BH, Lee JH, Kim JJ, Rhee PL

Background/Aims: A diagnosis of gastroesophageal reflux disease is challenging in patients who have reflux symptoms but do not respond to proton pump inhibitors nor have reflux esophagitis and hiatal hernia...
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Pharmacodynamic evaluation of YH4808 for Helicobacter pylori eradication in healthy subjects

Park H, Kim CO, Kim M, Lim Y, Lee WY, Yoon S, Park MS

YH4808 is a novel selective potassium-competitive acid blocker demonstrated to be safe and to have inhibitory effects against gastric acid secretion in previous studies. A randomized, open-label, multiple-dose, 3-treatment, 1-period,...
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Emerging Concepts of Motor Reserve in Parkinson’s Disease

Chung SJ, Lee JJ, Lee PH, Sohn YH

The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits...
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Establishment and Operation of Wartime Health Care System in North Korea during the Korean War and Support from the Korean Society in Yanbian

MOON M

North Korea's health care system during the Korean War has a significant meaning in North Korean medical history and is also an appropriate research topic for understanding North Korea's wartime...
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