J Korean Neurosurg Soc.  1985 Mar;14(1):61-70.

The Effect of Naloxone on Pathological Changes in the Experimental Spinal Cord Injury

• Chi MP
• Kim SH
• Shin KM

Abstract

The pathological lesion in spinal injury is usually more severe in the central gray matter and spreads centrifugally to surrounding white matter. Opiate antagonists, naloxone, by blocking the pathophysiologic effect of endorphins, should increase both mean arterial pressure and spinal cord blood flow and limit neurologic injury. Naloxone produce increase of lateral column blood flow and ameliorate the central gray matter ischemia. We have investigated the effects of naloxone on histopathological change in cats subjected to thoracic cord contusion. The histopathological evaluation of the injured spinal cords in naloxone-treated cats had less tissue damage than would be observed in time-matched standards. The acute histopathology in saline-treated cats had lesions typical of what we would expect in untreated cats, but the chronic histopathology had slightly better than typical that.

Keyword

Spinal cord injury; Naloxone; Ischemia

MeSH Terms

Animals
Arterial Pressure
Cats
Contusions
Endorphins
Ischemia
Naloxone*
Spinal Cord Injuries*
Spinal Cord*
Spinal Injuries
Endorphins
Naloxone