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The antinociceptive effect of artemisinin on the inflammatory pain and role of GABAergic and opioidergic systems

Dehkordi F, Kaboutari , Zendehdel , Javdani M

BACKGROUND: Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have...
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Small dose of naloxone as an adjuvant to bupivacaine in intrapleural infiltration after thoracotomy surgery: a prospective, controlled study

Amer AF, Omara AF

BACKGROUND: Severe pain always develops after thoracotomy; intrapleural regional analgesia is used as a simple, safe technique to control it. This study was performed to evaluate whether a small dose...
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Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain

Koh GH, Song H, Kim SH, Yoon MH, Lim KJ, Oh SH, Jung KT

BACKGROUND: This study was performed in order to examine the effect of intrathecal sec-O-glucosylhamaudol (SOG), an extract from the root of the Peucedanum japonicum Thunb., on incisional pain in a...
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Analgesic effects of eucalyptus essential oil in mice

Lee G, Park J, Kim MS, Seol GH, Min SS

BACKGROUND: The use of aroma oils dates back to at least 3000 B.C., where it was applied to mummify corpses and treat the wounds of soldiers. Since the 1920s, the...
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Participation of Opioid Pathway in the Central Antinociceptive Effects of Eugenol

Kang SH, Kang SW, Kim JH, Kim HY, Ryu HS, Bae SY, Oh JA, Lee JH, Hyun JH, Ahn DK

The aim of the present study was to evaluate the central antinociceptive effects of eugenol after intraperitoneal administration. Experiments were carried out using male Sprague-Dawley rats. Subcutaneous injection of 5%...
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Colorectal Transit and Volume During Treatment With Prolonged-release Oxycodone/Naloxone Versus Oxycodone Plus Macrogol 3350

Poulsen JL, Mark EB, Brock C, Frøkjær , Krogh K, Drewes AM

  • KMID: 2417279
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):119-127.
  • doi: 10.5056/jnm17058
BACKGROUND/AIMS: Opioid-induced constipation (OIC) is the most common gastrointestinal (GI) side effect to opioid treatment. Opioid receptor antagonists against OIC have been introduced, but their efficacy has not been directly...
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Opioid Withdrawal Symptoms after Conversion to Oral Oxycodone/Naloxone in Advanced Cancer Patients Receiving Strong Opioids

Kim JH, Song H, Lee GW, Kang JH

PURPOSE: Oral naloxone is combined with oxycodone to alleviate or prevent opioid-induced constipation in cancer pain patients. However, there is still concern that oral naloxone may precipitate opioid withdrawal symptoms...
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Antinociceptive effect of intrathecal sec-O-glucosylhamaudol on the formalin-induced pain in rats

Kim SH, Jong HS, Yoon MH, Oh SH, Jung KT

BACKGROUND: The root of Peucedanum japonicum Thunb., a perennial herb found in Japan, the Philippines, China, and Korea, is used as an analgesic. In a previous study, sec-O-glucosylhamaudol (SOG) showed...
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Vitamin E Potentiates the Anti-nociceptive Effects by Intraperitoneal Administration of Lidocaine in Rats

Kim HJ, Yang HJ, Kim SH, Kim DA, Kim SJ, Park HN, Ju JS, Ahn DK

The present study was to evaluate effects of vitamin E on intravenous administration of lidocaine-induced antinociception. Experiments were carried out using male Sprague-Dawley rats. Orofacial formalin-induced nociceptive behavioral responses were...
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Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity

Xia A, Xue Z, Wang W, Zhang T, Wei T, Sha X, Ding Y, Zhou W

To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley...
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A Case of Mental Change in a Patient Who Received a Zoletil Injection

Lee YK, Kang IG, Park CS, Heo SJ, Chai YS, Park SS, Lee JK, Kim HJ, Jeong WJ

  • KMID: 1482714
  • J Korean Soc Clin Toxicol.
  • 2013 Jun;11(1):23-27.
Zoletil is a non-opioid, non-barbiturate animal anesthetic and proprietary combination of two drugs, a dissociative anesthetic drug, tiletamine, with the benzodiazepine anxiolytic drug, zolazepam. Zoletil has greater potency than ketamine....
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Ginsenosides Have a Suppressive Effect on c-Fos Expression in Brain and Reduce Cardiovascular Responses Increased by Noxious Stimulation to the Rat Tooth

Jung JY, Seong KJ, Moon IO, Cho JH, Kim SH, Kim WJ

The purpose of this study is to investigate the antinociceptive effects of ginsenosides on toothache. c-Fos immunoreactive (IR) neurons were examined after noxious intrapulpal stimulation (NS) by intrapulpal injection of...
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Functional activity of the cannabinoid 1 receptor is not affected by opioid antagonists in the rat brain

Lee H

BACKGROUND: WIN55212-2 is a synthetic cannabinoid agonist and selective to cannabinoid 1 (CB1) receptors, which are distributed mainly in the central nervous system. Opioid receptors and CB1 receptors have several...
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Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study

Lee SK, Kim JH, Kim JS, Jang Y, Kim J, Park YH, Chun KJ, Lee MY

BACKGROUND: The activation of guanine nucleotide binding protein-coupled receptors, such as adenosine receptor (ADR) and opioid receptor (OPR), protects the heart against ischemia and reperfusion injury. We hypothesized that ADR...
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Hop Extract Produces Antinociception by Acting on Opioid System in Mice

Park SH, Sim YB, Kang YJ, Kim SS, Kim CH, Kim SJ, Seo JY, Lim SM, Suh HW

In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a...
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A Case of Delayed Administration of Naloxone for Morphine Intoxicated Patient

Kim GB, Park WN, Gu HD

  • KMID: 1437677
  • J Korean Soc Clin Toxicol.
  • 2012 Jun;10(1):33-36.
Opioids are the one of the most commonly used drugs to control cancer pain all over the world. But, we should not overlook the potential risk of opioid intoxication because...
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Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse

Park SH, Sim YB, Kang YJ, Lee JK, Lim SS, Suh HW

In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as...
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Morphine-induced postconditioning modulates mitochondrial permeability transition pore opening via delta-1 opioid receptors activation in isolated rat hearts

Kim JH, Chun KJ, Park YH, Kim J, Kim JS, Jang YH, Lee MY, Park JH

BACKGROUND: It is generally accepted that morphine affords cardioprotection against ischemia/reperfusion injury. Inhibition of the mitochondrial permeability transition pore (MPTP) is considered an end target for cardioprotection. The aim of...
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Cultured human chromaffin cells grafted in spinal subarachnoid space relieves allodynia in a pain rat model

Jeon Y, Baek WY, Chung SH, Shin N, Kim HR, Lee SA

BACKGROUND: Implantation of xenogenic chromaffin cells into the spinal subarachnoid space can produce analgesia in neuropathic pain models. However, transplantation of xenogeneic chromaffin cell has a potential risk of viral...
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Morphine Postconditioning Attenuates ICAM-1 Expression on Endothelial Cells

Min TJ, Kim JI, Kim JH, Noh KH, Kim TW, Kim WY, Lee YS, Park YC

The purpose of this study is to determine 1) whether morphine postconditiong (MPostC) can attenuate the intercellular adhesion molecules-1 (ICAM-1) expression after reoxygenation injury and 2) the subtype(s) of the...
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