Ewha Med J.  1988 Dec;11(4):299-309. 10.12771/emj.1988.11.4.299.

The Effect of Naloxone on Pathological Changes in the Experimental Spinal Cord Injury

• Kim SH

• KMID: 2170823
• DOI: http://doi.org/10.12771/emj.1988.11.4.299

Abstract

The object of this investigation was to study the effects of Naloxone on histopathological changes in cats subjected thoracic cord contusion. Twenty cats were divided 4 groups : The first group was sham control(3 Cats). The second group was the impact group that was induced by T9 cord injury without treatment(6 Cats). The third group was the saline group that was induced by T9 cord injury and treatment with Saline(6 Cats). The fourth group was the Naloxone group that was induced by T9 cord injury and treatment with Naloxone(6 Cats). The histopathological evaluation of the injured spinal cords in Naloxone-treated Cats had less tissue damage than would be observed in time-matched standards. The histopathology in Saline-treated group had slightly better than typical of what we would expect in impact group.

Keyword

Spinal cord injury; Ischemia; Naloxone

MeSH Terms

Animals
Cats
Contusions
Ischemia
Naloxone*
Spinal Cord Injuries*
Spinal Cord*
Naloxone