Korean J Urol.  1991 Apr;32(2):264-273.

Antimicrobial drug resistance of gram negative bacilli isolated from urine

• Seo BW
• Cha YB
• Park CH
• Lee SJ
• Baek WK
• Suh SI
• Suh MH

Abstract

One hundred and fifty strains of Gram negative bacilli isolated from urine of patients with urological disease were tested for resistance to antimicrobial drugs including quinolones. Escherichia coli (61 strains) was most frequently isolated, and followed by Klebsiella spp. (36), Pseudomonas aeruginosa (12). and Proteus spp. (6) in the decreasing order. New quinolone carboxylic acid compounds such as enoxacin (Ex). norfloxacin (Nf), ciprofloxacin (Cp), pefloxacin (Pf), and ofloxacin (Of) showed very high antimicrobial activities against the majority of organisms tested except P.aerogi. nose. In P.aeruginosa all strains were resistant to nalidixic acid, and 25-33% to Ex. Nf. Cp, Pf, and Or. The majority of strains tested were found to be resistant to beta-lactam antibiotics except moxalactam (Mr). aminoelycoside drugs except amikacin (Ak), and other drugs tested such as chloramphgnicol, tetracycline. rifampin and etc.. but in P.aeruginosa, 33-58% were resistant to Mx and Ak. Organisms multiplyine resistance to 5 or more druge were noted in almost all isolates tested The stain numbers of multiplying resistance to 5 or more drugs were 51 strains (83.6%) of E. Coli 24 strains (66.7%) of Klebsielle spp., 10 strains (83.3%) of P.aeruginosa, and 5 strains (83.3%) of Prorteus spp.

Keyword

Gram negative bacilli; Quinolone; Antimicrobial Resistance

MeSH Terms

Amikacin
Anti-Bacterial Agents
Ciprofloxacin
Drug Resistance, Microbial*
Enoxacin
Escherichia coli
Humans
Klebsiella
Moxalactam
Nalidixic Acid
Norfloxacin
Nose
Ofloxacin
Pefloxacin
Proteus
Pseudomonas aeruginosa
Quinolones
Rifampin
Tetracycline
Urologic Diseases
Amikacin
Anti-Bacterial Agents
Ciprofloxacin
Enoxacin
Moxalactam
Nalidixic Acid
Norfloxacin
Ofloxacin
Pefloxacin
Quinolones
Rifampin
Tetracycline