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Comparison of antimicrobial resistances and clinical features in community-onset Escherichia coli and Klebsiella pneumoniae bacteremia

Sung HS, Lee JW, Bae S, Kwon KT

Background/Aims: The aim of this study was to compare antimicrobial resistance, clinical features, and outcomes of community-onset Escherichia coli (COEC) and Klebsiella pneumoniae (COKP) bacteremia. Methods: The medical records of patients...
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Analysis of Genetic Mutations in Quinolone Resistance and Virulence Factor Gene Profile of Enterococcus faecalis

Lee SH, Noh GM, Lee SJ

Purpose: To investigate the resistance rate of Enterococcus faecalis which is one of the causative strains of endophthalmitis to three fluoroquinolone drugs, the quinolone resistance gene mutation patterns, and the...
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Genotypic characterization of fluoroquinolone-resistant Escherichia coli isolates from edible offal

Son SH, Seo KW, Kim YB, Noh EB, Lee KW, Oh TH, Kim SJ, Song JC, Kim TW, Lee YJ

Abstract: Edible offal is easily contaminated by Escherichia coli (E. coli) and fluoroquinolone (FQ)-resistant E. coli is considered a serious public health problem, thus, this study investigated the genetic characteristics...
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A Novel Mismatched PCR-Restriction Fragment Length Polymorphism Assay for Rapid Detection of gyrA and parC Mutations Associated With Fluoroquinolone Resistance in Acinetobacter baumannii

Kakuta N, Nakano R, Nakano A, Suzuki Y, Tanouchi A, Masui T, Horiuchi S, Endo S, Kakuta R, Ono Y, Yano H

BACKGROUND: Mutations in the quinolone resistance-determining regions (QRDRs) of Acinetobacter baumannii DNA gyrase (gyrA) and topoisomerase IV (parC) are linked to fluoroquinolone (FQ) resistance. We developed a mismatched PCR-restriction fragment...
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Usefulness of In Vivo and In Vitro Diagnostic Tests in the Diagnosis of Hypersensitivity Reactions to Quinolones and in the Evaluation of Cross-Reactivity: A Comprehensive Study Including the Latest Quinolone Gemifloxacin

Demir S, Gelincik A, Akdeniz N, Aktas-Cetin E, Olgac M, Unal D, Ertek B, Coskun R, ColakoÄŸlu B, Deniz G, Buyukozturk S

PURPOSE: Reports evaluating diagnosis and cross reactivity of quinolone hypersensitivity have revealed contradictory results. Furthermore, there are no reports investigating the cross-reactivity between gemifloxacin (GFX) and the others. We aimed...
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Quinolone susceptibility and genetic characterization of Salmonella enterica subsp. enterica isolated from pet turtles

De Silva B, Hossain S, Wimalasena SHMP, Pathirana , Wendt M, Heo GJ

Turtle-borne Salmonella enterica owns significance as a leading cause in human salmonellosis. The current study aimed to determine the quinolone susceptibility and the genetic characteristics of 21 strains of S....
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Mechanisms of quinolone resistance in Escherichia coli isolated from companion animals, pet-owners, and non-pet-owners

Chung YS, Hu YS, Shin S, Lim SK, Yang SJ, Park YH, Park KT

The present study investigated the prevalence and mechanisms of fluoroquinolone (FQ)/quinolone (Q) resistance in Escherichia (E.) coli isolates from companion animals, pet-owners, and non-pet-owners. A total of 63 E. coli...
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DRESS syndrome with acute interstitial nephritis caused by quinolone and non-steroidal anti-inflammatory drugs

Kim SJ, Nam YH, Juong JY, Kim EY, Lee SM, Son YK, Nam HJ, Kim KH, Lee SK

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and severe drug-induced hypersensitivity syndrome characterized by hematological abnormalities and multiorgan involvement. Liver involvement is the most common...
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The Antibiotic Resistance Pattern of Gram-Negative Bacteria in Children Younger Than 24 Months with a Urinary Tract Infection: A Retrospective Single-Center Study over 15 Consecutive Years

Lee YK, Lee H, Kim JM, Kang JM, Lee ST, Lee NY, Kim YJ, Cho H

PURPOSE: We investigated trends in antibiotic resistance for gram-negative bacteria in infants with a urinary tract infection (UTI) over 15 years at a single institution. METHODS: A retrospective chart review was...
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Molecular Detection of Fluoroquinolone Resistance in Multidrug-Resistant Mycobacterium tuberculosis Isolates

Kim CK, Lee BS, Choi MJ, Kim HJ, Lee K

BACKGROUND: Fluoroquinolones (FQs) are important drugs for treating multidrug-resistant tuberculosis (MDR-TB). However, due to widespread use of FQs, the resistance rates to FQs have been increasing among Mycobacterium tuberculosis. Rapid...
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Correlation Between Virulence Genotype and Fluoroquinolone Resistance in Carbapenem-Resistant Pseudomonas aeruginosa

Cho HH, Kwon KC, Kim S, Koo SH

BACKGROUND: Pseudomonas aeruginosa is a clinically important pathogen that causes opportunistic infections and nosocomial outbreaks. Recently, the type III secretion system (TTSS) has been shown to play an important role...
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Clinical Importance and Epidemiology of Quinolone Resistance

Kim ES, Hooper DC

The quinolone class of antimicrobial agents is one of most widely used classes of antimicrobial agents in outpatient and inpatient treatment. However, quinolone resistance in gram-positive and gram-negative bacteria has...
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Molecular Investigation of Quinolone Resistance of Quinolone Resistance-Determining Region in Streptococcus pneumoniae Strains Isolated from Iran Using Polymerase Chain Reaction–Restriction Fragment Length Polymorphism Method

Kargar M, Moein Jahromi F, Doosti A, Handali S

Objectives The resistance of Streptococcus pneumoniae to the recently available antibiotic treatment has been a growing problem. The aim of the study was to determine the quinolone-resistant strains and detect the...
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Febrile Urinary Tract Infection After Prostate Biopsy and Quinolone Resistance

Choi JW, Kim TH, Chang IH, Kim KD, Moon YT, Myung SC, Kim JW, Kim MS, Kwon JK

PURPOSE: Complications after prostate biopsy have increased and various causes have been reported. Growing evidence of increasing quinolone resistance is of particular concern. In the current retrospective study, we evaluated...
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Efflux-mediated resistance identified among norfloxacin resistant clinical strains of group B Streptococcus from South Korea

Dang TN, Srinivasan U, Britt Z, Marrs CF, Zhang L, Ki M, Foxman B

OBJECTIVES: Group B Streptococcus (GBS), a common bowel commensal, is a major cause of neonatal sepsis and an emerging cause of infection in immune-compromised adult populations. Fluoroquinolones are used to...
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Inappropriateness of Quinolone in Scrub Typhus Treatment Due to gyrA Mutation in Orientia tsutsugamushi Boryong Strain

Jang HC, Choi SM, Jang MO, Ahn JH, Kim UJ, Kang SJ, Shin JH, Choy HE, Jung SI, Park KH

The use of quinolone for treatment of rickettsial diseases remains controversial. Recent clinical studies suggest that quinolone is not as effective as others in patients with rickettsial diseases including scrub...
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Quinolone-resistant Shigella flexneri Isolated in a Patient Who Travelled to India

Jeon YL, Nam YS, Lim G, Cho SY, Kim YT, Jang JH, Kim J, Park M, Lee HJ

We report a recent case in which ciprofloxacin-resistant Shigella flexneri was isolated from a 23-yr-old female patient with a history of travel to India. Prior to her admission to our...
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The Choice of Empirical Treatment of Uncomplicated Cystitis: No Longer Free Ride

Kim TH

Resistance of uropathogenic E. coli to trimethoprim/sulfamethoxazole in Korea has surpassed the threshold of 20% at which the drug is no longer recommended for empirical treatment and routine urine culture...
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Multiplex Real-Time Polymerase Chain Reaction-Based Method for the Rapid Detection of gyrA and parC Mutations in Quinolone-Resistant Escherichia coli and Shigella spp.

Kim J, Jeon S, Kim H, Park M, Kim S, Kim S

Two real-time polymerase chain reaction assays were developed to detect mutations in codons 83 and 87 in gyrA and in codons 80 and 91 in parC, the main sites that...
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Genetic Classification and Antimicrobial Resistance of Ureaplasma urealyticum Isolated from Urine

Choi M, Park I

Recently, polymerase chain reaction (PCR)-based methods have been used to reclassify Ureaplasma urealyticum into two independent species (spp.), designating U. parvum and U. urealyticum. In the current study, we aim...
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