Korean J Clin Microbiol.
2009 Sep;12(3):103-109. 10.5145/KJCM.2009.12.3.103.
Metallo-beta-lactamase Producing Gram-negative Bacilli
- Affiliations
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- 1Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea. deyong@yuhs.ac
- KMID: 1828579
- DOI: http://doi.org/10.5145/KJCM.2009.12.3.103
Abstract
- Among gram-negative bacteria, rate of antibiotic resistance has been increasing. As a result, carbapenem is now considered as a last resort of therapeutic regimens for gram-negative bacterial infections. The choice of antibiotics has been impeded by the spread of organisms producing metallo-beta-lactamases (MBL), which can confer resistance to nearly all beta-lactams. MBLs have extremely diverse structures and are carried by various organisms including human pathogens. This review will focus on the classification and current status of MBL reported in Korea.
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