Yonsei Med J.  2015 Mar;56(2):572-577. 10.3349/ymj.2015.56.2.572.

Increasing Carbapenem-Resistant Gram-Negative Bacilli and Decreasing Metallo-beta-Lactamase Producers over Eight Years from Korea

• Lee Y
• Kim CK
• Chung HS
• Yong D
• Jeong SH
• Lee K
• Chong Y

• KMID: 2070040
• DOI: http://doi.org/10.3349/ymj.2015.56.2.572

Abstract

The trends and types of carbapenemase-producing Gram-negative bacilli were analyzed from clinical specimens collected between 2005 and 2012 at a Korean teaching hospital. The proportions of carbapenem-resistant Acinetobacter spp. increased markedly to 66%. Metallo-beta-lactamase producers significantly decreased and the majority shifted from the bla(VIM-2) type to the bla(IMP-1) type.

Keyword

Gram-negative bacilli; carbapenem; metallo-beta-lactamase

MeSH Terms

Acinetobacter/classification/drug effects/*enzymology
Acinetobacter Infections/drug therapy
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins
Carbapenems/*pharmacology
Drug Resistance, Microbial
Gram-Negative Bacteria/*drug effects/enzymology/isolation & purification
Humans
Incidence
Microbial Sensitivity Tests/trends
Population Surveillance
Pseudomonas/classification/drug effects/enzymology
Republic of Korea/epidemiology
beta-Lactamases/biosynthesis/*drug effects
Anti-Bacterial Agents
Bacterial Proteins
Carbapenems
beta-Lactamases