Tuberc Respir Dis.
2002 Dec;53(6):662-672. 10.4046/trd.2002.53.6.662.
Four Fatal Cases of Amiodarone-Induced Pulmonary Toxicity
- Affiliations
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- 1Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea. mdlee@catholic.ac.kr
- 2Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Seoul, Korea.
- KMID: 1877042
- DOI: http://doi.org/10.4046/trd.2002.53.6.662
Abstract
- The lungs are frequently the site of adverse drug reactions because of their higher oxygen concentration, the distinctive properties of the pulmonary circulation, and the close proximity of the alveolar epithelium to the blood. Amiodarone, an iodinated benzofuran derivative, is an effective antiarrhythmic drug commonly used for refractory tachyarrhythmia. However, it has a wide range of adverse effects, the most serious of which is lung disease. Most patients present with the insidious onset of dyspnea and a nonproductive cough, and generally recover after withdrawing the drug. We recently experienced four fatal cases of amiodarone pulmonary toxicity. Therefore, we discuss these unusual drug-induced pulmonary toxicity cases with a review of the relevant literature.
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