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Evaluation of Drug-Induced Liver Injury Developed During Hospitalization Using Electronic Health Record (EHR)-Based Algorithm

Kang Y, Kim SH, Park SY, Park BY, Lee JH, An J, Won HK, Song WJ, Kwon HS, Cho YS, Moon HB, Shim JH, Yang MS, Kim TB

PURPOSE: The incidence of drug-induced liver injury (DILI) has been increasing; however, few algorithms are available to identify DILI in electronic health records (EHRs). We aimed to identify and evaluate...
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Extracting Structured Genotype Information from Free-Text HLA Reports Using a Rule-Based Approach

Lee KH, Kim HJ, Kim YJ, Kim JH, Song EY

BACKGROUND: Human leukocyte antigen (HLA) typing is important for transplant patients to prevent a severe mismatch reaction, and the result can also support the diagnosis of various disease or prediction...
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Acute Acalculous Cholecystitis Associated with Sunitinib Treatment for Renal Cell Carcinoma

Choi SW, Lee JM, Kim DG, Noh MH

A 64-year-old man was treated with sunitinib as a first-line therapy for metastatic renal cell carcinoma. He was given oral sunitinib in cycles of 50 mg once daily for 2...
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Peripheral blood immune cell-based biomarkers in anti-PD-1/PD-L1 therapy

Kim KH, Kim CG, Shin EC

Immune checkpoint blockade targeting PD-1 and PD-L1 has resulted in unprecedented clinical benefit for cancer patients. Anti-PD-1/PD-L1 therapy has become the standard treatment for diverse cancer types as monotherapy or...
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Current Guidelines for Non-Steroidal Anti-Inflammatory Drugs

Park MG, Yoo JD, Lee KH

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide for chronic pain, such as arthritis, and there are many different types depending on their composition and mechanism. After...
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Comparison of Two Combinations of Maximum Medical Therapy for Lowering Intraocular Pressure in Primary Open-angle Glaucoma

Wy S, Kim YK, Jeoung JW, Park KH, Ha A

PURPOSE: We sought to compare the efficacy as well as the safety of two maximum medical therapy combinations applied to lower the intraocular pressure (IOP) in different primary open-angle glaucoma...
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Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008–2017

Kim HK, Kim DY, Bae EK, Kim DW

BACKGROUND: Severe and life-threatening drug eruptions include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). One class of medications that has been...
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Prediction of Drug–Drug Interactions by Using Profile Fingerprint Vectors and Protein Similarities

Dere S, Ayvaz S

OBJECTIVES: Drug–drug interaction (DDI) is a vital problem that threatens people's health. However, the prediction of DDIs through in-vivo experiments is not only extremely costly but also difficult as many...
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Real-Life Effectiveness and Tolerability of Perampanel in Pediatric Patients Aged 4 Years or Older with Epilepsy: A Korean National Multicenter Study

Hwang SK, Lee YJ, Nam SO, Kim WS, Kim JS, Kim SJ, Lee YJ, Kwon S

BACKGROUND AND PURPOSE: The US Food and Drug Administration approval for perampanel has only recently been expanded to patients as young as 4 years, and so there have been few...
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Efficacy and Tolerability of Low-Dose Perampanel in Patients with Childhood-Onset Intractable Epilepsy

Park H, Ahn H, Jang HN, Kim HJ, Yum MS, Ko TS

PURPOSE: The aim of this study was to evaluate the efficacy and tolerability of perampanel as adjunctive therapy in childhood-onset refractory epilepsy. METHODS: We retrospectively reviewed the medical records of 110...
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Efficacy and Tolerability of Low-Dose Perampanel in Patients with Childhood-Onset Intractable Epilepsy

Park H, Ahn H, Jang HN, Kim HJ, Yum MS, Ko TS

PURPOSE: The aim of this study was to evaluate the efficacy and tolerability of perampanel as adjunctive therapy in childhood-onset refractory epilepsy. METHODS: We retrospectively reviewed the medical records of 110...
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Adverse drug reactions

Cho MK, Kang DY, Kang HR

There are no drugs without the risk of potential adverse reactions. All pharmacologically active substances can cause adverse drug reactions (ADRs). This paper aims at introducing recent trends in pharmacosurveillance...
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Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment

Kim TO, Shin HJ, Kim YI, Lim SC, Koh YI, Kwon YS

BACKGROUND/AIMS: Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral...
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Rhabdomyolysis and Neuroleptic Malignant Syndrome Associated with Very Low-dose Antipsychotics in Children and Adolescent

Park JI, Park TW

Along with the field of adult psychiatry, antipsychotic agents are increasingly used in the field of child and adolescent psychiatry. Although neuroleptic malignant syndrome (NMS) and rhabdomyolysis are rare complication...
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Why should we monitor for hematologic adverse drug reactions to oxcarbazepine?

Jang GC

No abstract available.
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Lipid emulsion therapy of local anesthetic systemic toxicity due to dental anesthesia

Rhee SH, Park SH, Ryoo SH, Karm MH

Local anesthetic systemic toxicity (LAST) refers to the complication affecting the central nervous system (CNS) and cardiovascular system (CVS) due to the overdose of local anesthesia. Its reported prevalence is...
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Systemic effects of fluoroscopically guided epidural steroid injection with dexamethasone

Kang WY, Lee JW, Lee E, Kang Y, Ahn JM, Kang HS

BACKGROUND: Epidural steroid injections (ESIs) have been widely used in managing spinal pain. Dexamethasone has recently emerged as a useful drug in this setting, relative to particulate steroids, although the...
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Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond

Nguyen DV, Vidal C, Chu HC, van Nunen

Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%–50%) and...
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Safety and efficacy in actual clinical practice of once-weekly subcutaneous teriparatide for osteoporosis patients with a high fracture risk

Ifuku E, Yoshimura , Uzawa T, Hokonohara T

OBJECTIVES: To reassess the safety and efficacy of once-weekly teriparatide 56.5 mg in osteoporosis patients with a high fracture risk. METHODS: This postmarketing observational study was conducted at 72 weeks according...
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Visual Field Defect after Taking Atorvastatin/Ezetimibe, a Case Study

Kim J, Lee K, Kim J, Lee JM, Kim NY, Lee MS, Ji E

Atorvastatin is one of the most widely prescribed medications for dyslipidemia treatment. In Korea, post combined therapy with ezetimibe, a 73-year-old woman was reported by a community pharmacy to have...
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