- Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review
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Lee SH, Sohn JT
- KMID: 2542496
- Korean J Anesthesiol.
- 2023 Jun;76(3):171-182.
- doi: 10.4097/kja.23031
Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST). LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local anesthetic drug toxicity. This review aims... -
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- Management of adverse events in young adults and children with acute B-cell lymphoblastic leukemia receiving anti-CD19 chimeric antigen receptor (CAR) T-cell therapy
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Yoo JW
- KMID: 2541979
- Blood Res.
- 2023 Apr;58(S1):20-28.
- doi: 10.5045/br.2023.2023026
With impressive clinical advancements in immune effector cell therapies targeting CD19, chimeric antigen receptor (CAR) T-cell therapy has emerged as a new paradigm for treating relapsed/refractory B-cell malignancies. Currently, three... -
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- Ameliorative effects of propolis upon reproductive toxicity in males
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Banihani SA
- KMID: 2540242
- Clin Exp Reprod Med.
- 2023 Mar;50(1):12-18.
- doi: 10.5653/cerm.2022.05785
Propolis is a sticky natural product produced by honeybees. Research studies have discussed the effectiveness of propolis, directly or indirectly, for ameliorating reproductive toxicity in males; however, this research has... -
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- Assessment of acute inhalation toxicity of citric acid and sodium hypochlorite in rats
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Kim J, Park CM, Choi SH, Yang MJ, Lee JY, Jeon BS, Ku HO, Kim MS
- KMID: 2541335
- J Vet Sci.
- 2023 Mar;24(2):e22.
- doi: 10.4142/jvs.22253
Background: Citric acid (CA) and sodium hypochlorite (NaOCl) have been used to disinfect animals to protect them against avian influenza and foot-and-mouth disease. Objectives: We performed a good laboratory practice (GLP)-compliant... -
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- A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids
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Park SB, Jung WH, Choi KJ, Koh B, Kim KY
- KMID: 2539231
- Tissue Eng Regen Med.
- 2023 Feb;20(1):49-58.
- doi: 10.1007/s13770-022-00496-8
BACKGROUND: Microplastics (MPs) are small fragments from any type of plastic formed from various sources, including plastic waste and microfibers from clothing. MPs degrades slowly, resulting in a high probability... -
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- Twenty-eight-day oral dose toxicity evaluation of SUNACTIVE Fe-P80 in rats
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Lim JH, Park MK, Seo HS, Kim SH, Kim WI, Shin IS, Kim JC
- KMID: 2538511
- J Biomed Transl Res.
- 2022 Dec;23(4):131-149.
- doi: 10.12729/jbtr.2022.23.4.131
Iron deficiency is known to be a common nutritional disorder in many countries, especially among children, women of childbearing age and pregnant women. SUNACTIVE Fe-P80 is a new type of... -
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- Toxicological properties of the Thyrokitty injection (I-131) for the treatment of the feline hyperthyroidism
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Lim JC, Kim DM, Nam SS, Cho EH, Lee SY, Chung HK, Lee I
- KMID: 2538508
- J Biomed Transl Res.
- 2022 Dec;23(4):179-189.
- doi: 10.12729/jbtr.2022.23.4.179
Following the previous study, the toxicity of a single subcutaneous administration of the Thyrokitty injection (I-131) and the side effects that may occur at therapeutic doses were con-firmed. The Thyrokitty... -
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- Acute inhalation toxicity assessment of 2-{2-[2-(4-nonylphenoxy)ethoxy]ethoxy}ethan-1-ol in Sprague-Dawley rats
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Cho ES, Jang JY
- KMID: 2538504
- J Biomed Transl Res.
- 2022 Dec;23(4):235-239.
- doi: 10.12729/jbtr.2022.23.4.235
The surfactant, 2-{2-[2-(4-nonylphenoxy)ethoxy]ethoxy}ethan-1-ol, is used in detergents, pesticides, cosmetics, and disinfectants. Since it is found in products that can be inhaled, we evaluated its toxicity to humans upon exposure. A... -
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- Patterns of failure for hypopharynx cancer patients treated with limited high-dose radiotherapy treatment volumes
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Burr A, Harari P, Wieland A, Kimple R, Hartig G, Witek M
- KMID: 2538833
- Radiat Oncol J.
- 2022 Dec;40(4):225-231.
- doi: 10.3857/roj.2022.00311
Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the... -
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- Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus
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Okogwu OI, Elebe FA, Nwonumara GN
- KMID: 2539832
- Environ Anal Health Toxicol.
- 2022 Dec;37(4):e2022028.
- doi: 10.5620/eaht.2022028
Cypermethrin and dimethoate are pesticides frequently used in agriculture to eliminate pests. Contemporaneity of these and other pesticides in commercial preparations and several aquatic ecosystems is well known, though poorly... -
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- The UGT1A9*22 genotype identifies a high-risk group for irinotecan toxicity among gastric cancer patients
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Lee Ck, Chon HJ, Kwon WS, Ban HJ, Kim SC, Kim H, Jeung HC, Chung J, Rha SY
- KMID: 2535364
- Genomics Inform.
- 2022 Sep;20(3):e29.
- doi: 10.5808/gi.22051
Several studies have shown associations between irinotecan toxicity and UGT1A genetic variations in colorectal and lung cancer, but only limited data are available for gastric cancer patients. We evaluated the... -
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- Calcium carbide–induced derangement of hematopoiesis and organ toxicity ameliorated by cyanocobalamin in a mouse model
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Ouma PA, Mwaeni VK, Amwayi PW, Isaac AO, Nyariki JN
- KMID: 2534146
- Lab Anim Res.
- 2022 Sep;38(3):193-208.
- doi: 10.1186/s42826-022-00136-1
Background: Calcium carbide (CaC 2 ) is a chemical primarily used in the production of acetylene gas. The misuse of CaC 2 to induce fruit ripening is a global challenge... -
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- Evaluation of the toxicological effects of atrazine-metolachlor in male rats: in vivo and in silico studies
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Olayinka ET, Ore A, Adewole KE, Oyerinde O
- KMID: 2534365
- Environ Anal Health Toxicol.
- 2022 Sep;37(3):e2022021.
- doi: 10.5620/eaht.2022021
The types and mechanisms of atrazine-metolachlor toxicity, an herbicide composed of atrazine (ATR) and metolachlor (MET), need to be further investigated. This study evaluated the toxic actions of ATR-MET by... -
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- Reproductive and developmental toxicity screening test of new TiO2 GST in Sprague-Dawley rats
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Baek HS, Park MK, Kim HM, Im JM, Seo HS, Park HJ, Nah SS
- KMID: 2534362
- Environ Anal Health Toxicol.
- 2022 Sep;37(3):e2022018.
- doi: 10.5620/eaht.2022018
TiO2 nanoparticles are widely used in paints, plastics, cosmetics, printing ink, rubber, food products, pharmaceuticals and other products (photocatalyst, etc.). However, there is little toxicological information during reproduction and developmental... -
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- Establishment of Neurotoxicity Assessment Using Microelectrode Array (MEA) with hiPSC-Derived Neurons and Evaluation of New Psychoactive Substances (NPS)
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Kang Kr, Kim CY, Kim J, Ryu B, Lee SG, Baek J, Kim YJ, Lee JM, Lee Y, Choi SO, Woo DH, Park IH, Chung HM
- KMID: 2532400
- Int J Stem Cells.
- 2022 Aug;15(3):258-269.
- doi: 10.15283/ijsc21217
Background and Objectives: Currently, safety pharmacological tests for the central nervous system depend on animal behavioral analysis. However, due to the subjectivity of behavioral analysis and differences between species, there... -
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- Comparison of laxative effects of fermented soybeans (Cheonggukjang) containing toxins and biogenic amines against loperamide-induced constipation mouse model
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Kim HR, Park IS, Park SB, Yang HJ, Jeong DY, Kim SY
- KMID: 2532094
- Nutr Res Pract.
- 2022 Aug;16(4):435-449.
- doi: 10.4162/nrp.2022.16.4.435
BACKGROUND/OBJECTIVES: (Cheonggukjang) is a traditional fermented soybean paste with significant health-promoting effects. On the other hand, there have been insufficient studies on the safety and efficacy of (Cheonggukjang), which is... -
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- Hepatotoxic mechanism of diclofenac sodium on broiler chicken revealed by iTRAQ-based proteomics analysis
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Sun C, Zhu T, Zhu Y, Li B, Zhang J, Liu Y, Juan C, Yang S, Zhao Z, Wan R, Lin S, Yin B
- KMID: 2532282
- J Vet Sci.
- 2022 Jul;23(4):e56.
- doi: 10.4142/jvs.22018
Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives:... -
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- Chronological Analysis of Acute Hematological Outcomes after Proton and Photon Beam Craniospinal Irradiation in Pediatric Brain Tumors
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Yoo GS, Yu JI, Cho S, Han Y, Oh Y, Lim DH, Nam HR, Lee JW, Sung KW, Shin HJ
- KMID: 2531336
- Cancer Res Treat.
- 2022 Jul;54(3):907-916.
- doi: 10.4143/crt.2021.332
Purpose This study aimed to compare the early hematological dynamics and acute toxicities between proton beam craniospinal irradiation (PrCSI) and photon beam craniospinal irradiation (PhCSI) for pediatric brain tumors. Materials and Methods... -
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- Accelerated hypofractionated breast radiotherapy with simultaneous integrated boost: a feasibility study
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Yadav BS, Gupta S, Dahiya D, Gupta A, Oinam AS
- KMID: 2532064
- Radiat Oncol J.
- 2022 Jun;40(2):127-140.
- doi: 10.3857/roj.2021.01053
Purpose: To assess the feasibility of accelerated hypofractionated radiotherapy with simultaneous integrated boost (SIB) in patients with breast cancer. Materials and Methods: A total of 27 patients after breast-conserving surgery were... -
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- Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats
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Ilechukwu I, Ehigiator BE, Ben IO, Okonkwo CJ, Olorunfemi OS, Modo UE, Ilechukwu CE, Ohagwa NJ
- KMID: 2531408
- Environ Anal Health Toxicol.
- 2022 Jun;37(2):e2022015.
- doi: 10.5620/eaht.2022015
Microplastics have become a significant environmental concern. However, information on toxicity of microplastics in terrestrial organisms is limited. In this study, the chronic toxic effects of polystyrene microplastics (PS-MPs) on... -
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