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Zinc and selenium supplement mitigated valproic acid-induced testis toxicity by modulating the oxidative redox balance in male rats

Naderi M, Ahangar N, Badakhshan F, Ghasemi M, Shaki F

Valproic acid (VPA) is widely used antiepileptic agent which is associated with reproductive toxicity via impairment in oxidative redox. Zinc (Zn) and selenium (Se) are trace element with antioxidant effect...
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Safety and efficacy of 10-fraction hypofractionated radiation therapy for non-small cell lung cancer

Yoo YJ, Kim SS, Song SY, Kim JH, Ahn SD, Lee Sw, Yoon SM, Kim YS, Park Jh, Jung J, Choi EK

Purpose: To investigate the safety and efficacy of hypofractionated radiation therapy (HFRT) in patients with non-small cell lung cancer who are unfit for surgery or stereotactic body radiation therapy (SBRT)...
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Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor

Beladiya JV, Mehta AA

Background: The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one)...
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Motilitone toxicity in a dog

Kim YH, Ahn JO, Jeong Y, Kang MS, Choi JH, Chung JY

A three-month-old, intact male Maltese dog was presented to the hospital with lethargy after taking human medication, Motilitone. Physical examination, including a neurological examination, revealed no remarkable findings, but cholinergic...
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update

Chai JY, Jung BK, Hong SJ

The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are known to block the microtubule...
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Toxicity assessment of dimethyl carbonate following 28 days repeated inhalation exposure

Seo D

Dimethyl carbonate (DMC) has been used as a reagent in methylation reactions, can be used as paints, coatings, and adhesives, and is a chemical that is being used increasing, which...
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Nanoemulsions with Chloroaluminium Phthalocyanine and Paromomycin for Combined Photodynamic and Antibiotic Therapy for Cutaneous Leishmaniasis

Pinto SML, Muehlmann LA, Ojeda LLM, Arias AMV, Cordero MVR, Santos MdFMA, Azevedo RB, Rivero PE

Background: Photodynamic therapy (PDT) using chloroaluminium phthalocyanine (ClAlPc) and paromomycin sulfate (PM) can be effective against New World Leishmania species involved in cutaneous leishmaniasis (CL). The aim of this study...
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Pancreaticoduodenectomy with combined hepatic artery and portal vein resection after laparoscopic division of pancreaticosplenic ligament due to FOLFIRINOX-induced hepatic toxicity related secondary hypersplenism

Kim JS, Park JY, Choi M, Joo DJ, Hwang HK, Lee WJ, Kang CM

Pancreatic cancer is one of the dismal malignant disease in gastrointestinal tract. However, since the recent literature reporting median survival of FOLFIRINOX (leucovorin clcium, fluorouracil, irinotecan hydrochloride, oxaliplatin) chemotherapy was...
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Two Cases of Toxic Keratoconjunctivitis due to Ginkgo Nut Contact

Oh JS, Choi MY, Cho YK

Purpose: To report two cases of keratoconjunctivitis induced by gingko nut contact. Case summary: These cases report two old patients with severe keratoconjunctivitis who had recently touched ginkgo nuts and then...
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A randomized prospective study comparing acute toxicity, compliance and objective response rate between simultaneous integrated boost and sequential intensity-modulated radiotherapy for locally advanced head and neck cancer

Grover A, Soni TP, Patni N, Singh DK, Jakhotia N, Gupta AK, Sharma LM, Sharma S, Gothwal RS

Purpose: Intensity-modulated radiotherapy (IMRT) provides higher dose to target volumes and limits the dose to normal tissues. IMRT may be applied using either simultaneous integrated boost (SIB-IMRT) or sequential boost...
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Developmental toxicity of cadmium in infants and children: a review

Chandravanshi L, Shiv K, Kumar S

Several millions of people are exposed to cadmium worldwide due to natural and anthropogenic activities that led to their widespread distribution in the environment and have shown potential adverse effects...
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Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress

Kim M, Lee EJ, Lim KM

Over 30 million prescriptions of NSAIDs (non-steroidal anti-inflammatory drugs) are issued every year. Considering that these drugs are available without a prescription as over the counter (OTC) drugs, their use...
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Multilayered Cell Sheets of Cardiac Reprogrammed Cells for the Evaluation of Drug Cytotoxicity

Kwon SP, Song SY, Yoo J, Kim HY, Lee JR, Kang M, Sohn HS, Go S, Jung M, Hong J, Lim S, Kim C, Moon S, Char K, Kim BS

BACKGROUND: Various cell-culture systems have been used to evaluate drug toxicity in vitro. However, factors that affect cytotoxicity outcomes in drug toxicity evaluation systems remain elusive. In this study, we...
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Liver Function Analyses and Spleen Histology Assessment Following the Co-administration of Cisplatin and Methanolic Extract of Portulaca Oleracea in Wistar Rats: An Experimental Study

Okafor IA, Nnamah US, Nnaka J

This study investigated the biochemical and histological changes associated with the co-administration of cisplatin and methanolic extract of Portulaca Oleracea (MEPO) in adult Wistar rats. Twenty-four (24) adult female Wistar...
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Assessment of the cytotoxic and mutagenic potential of dichlorvos (DDVP) using in silico classification model; a health hazard awareness in Nigeria

Abaukaka YA, Sanusi S, Ozigi KA, Malo FU

Dichlorvos (DDVP) has been abused in Nigeria for suicide attempts, topical applications to treat an ectoparasitic infestation, and indiscriminate use on farm produce. Exposure to this compound in subacute concentration...
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Vandetanib for the Management of Advanced Medullary Thyroid Cancer: A Real-World Multicenter Experience

Kim M, Yoon JH, Ahn J, Jeon MJ, Kim HK, Lim DJ, Kang HC, Kim IJ, Shong YK, Kim TY, Kim BH

Background: Vandetanib is the most widely used tyrosine kinase inhibitor for the treatment of patients with advanced medullary thyroid cancer (MTC). However, only limited data regarding its use outside clinical...
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Cardiovascular Complications of Novel Anti-Cancer Immunotherapy: Old Problems from New Agents?

Chung WB, Youn JC, Youn HJ

Many novel anti-cancer therapies have dramatically improved outcomes of various cancer patients. However, it also poses a risk for cardiovascular complications as well. For the novel anti-cancer agent with which...
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Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation

Kim B, Yun J, Park B

Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to drug addiction and causes serious health...
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Cichorium intybus L. extract ameliorates testicular oxidative stress induced by lead acetate in male rats

Dorostghoal M, Seyyednejad SM, Nejad MNT

Objective Oxidative stress has been suggested as a possible mechanism for the adverse effects of heavy metal toxicity on male reproduction. Cichorium intybus L. is used in Iranian folk medicine as...
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Development of chitosan-catechol conjugates as mucoadhesive polymer: assessment of acute oral toxicity in mice

Kaur L, Raj R, Thakur AK, Singh I

Development of modified polymers is the focused area of research for developing stable, effective, sustainable and economical polymeric materials for developing different drug delivery systems. Modification of chitosan by catechol...
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