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Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review

Lee SH, Sohn JT

Currently, lipid emulsion (LE) is widely used to treat local anesthetic systemic toxicity (LAST). LE also ameliorates intractable cardiovascular collapse caused by lipid-soluble non-local anesthetic drug toxicity. This review aims...
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Management of adverse events in young adults and children with acute B-cell lymphoblastic leukemia receiving anti-CD19 chimeric antigen receptor (CAR) T-cell therapy

Yoo JW

With impressive clinical advancements in immune effector cell therapies targeting CD19, chimeric antigen receptor (CAR) T-cell therapy has emerged as a new paradigm for treating relapsed/refractory B-cell malignancies. Currently, three...
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Ameliorative effects of propolis upon reproductive toxicity in males

Banihani SA

Propolis is a sticky natural product produced by honeybees. Research studies have discussed the effectiveness of propolis, directly or indirectly, for ameliorating reproductive toxicity in males; however, this research has...
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Assessment of acute inhalation toxicity of citric acid and sodium hypochlorite in rats

Kim J, Park CM, Choi SH, Yang MJ, Lee JY, Jeon BS, Ku HO, Kim MS

Background: Citric acid (CA) and sodium hypochlorite (NaOCl) have been used to disinfect animals to protect them against avian influenza and foot-and-mouth disease. Objectives: We performed a good laboratory practice (GLP)-compliant...
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A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids

Park SB, Jung WH, Choi KJ, Koh B, Kim KY

BACKGROUND: Microplastics (MPs) are small fragments from any type of plastic formed from various sources, including plastic waste and microfibers from clothing. MPs degrades slowly, resulting in a high probability...
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Twenty-eight-day oral dose toxicity evaluation of SUNACTIVE Fe-P80 in rats

Lim JH, Park MK, Seo HS, Kim SH, Kim WI, Shin IS, Kim JC

Iron deficiency is known to be a common nutritional disorder in many countries, especially among children, women of childbearing age and pregnant women. SUNACTIVE Fe-P80 is a new type of...
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Toxicological properties of the Thyrokitty injection (I-131) for the treatment of the feline hyperthyroidism

Lim JC, Kim DM, Nam SS, Cho EH, Lee SY, Chung HK, Lee I

Following the previous study, the toxicity of a single subcutaneous administration of the Thyrokitty injection (I-131) and the side effects that may occur at therapeutic doses were con-firmed. The Thyrokitty...
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Acute inhalation toxicity assessment of 2-{2-[2-(4-nonylphenoxy)ethoxy]ethoxy}ethan-1-ol in Sprague-Dawley rats

Cho ES, Jang JY

The surfactant, 2-{2-[2-(4-nonylphenoxy)ethoxy]ethoxy}ethan-1-ol, is used in detergents, pesticides, cosmetics, and disinfectants. Since it is found in products that can be inhaled, we evaluated its toxicity to humans upon exposure. A...
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Patterns of failure for hypopharynx cancer patients treated with limited high-dose radiotherapy treatment volumes

Burr A, Harari P, Wieland A, Kimple R, Hartig G, Witek M

Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the...
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Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus

Okogwu OI, Elebe FA, Nwonumara GN

Cypermethrin and dimethoate are pesticides frequently used in agriculture to eliminate pests. Contemporaneity of these and other pesticides in commercial preparations and several aquatic ecosystems is well known, though poorly...
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The UGT1A9*22 genotype identifies a high-risk group for irinotecan toxicity among gastric cancer patients

Lee Ck, Chon HJ, Kwon WS, Ban HJ, Kim SC, Kim H, Jeung HC, Chung J, Rha SY

Several studies have shown associations between irinotecan toxicity and UGT1A genetic variations in colorectal and lung cancer, but only limited data are available for gastric cancer patients. We evaluated the...
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Calcium carbide–induced derangement of hematopoiesis and organ toxicity ameliorated by cyanocobalamin in a mouse model

Ouma PA, Mwaeni VK, Amwayi PW, Isaac AO, Nyariki JN

Background: Calcium carbide (CaC 2 ) is a chemical primarily used in the production of acetylene gas. The misuse of CaC 2 to induce fruit ripening is a global challenge...
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Evaluation of the toxicological effects of atrazine-metolachlor in male rats: in vivo and in silico studies

Olayinka ET, Ore A, Adewole KE, Oyerinde O

The types and mechanisms of atrazine-metolachlor toxicity, an herbicide composed of atrazine (ATR) and metolachlor (MET), need to be further investigated. This study evaluated the toxic actions of ATR-MET by...
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Reproductive and developmental toxicity screening test of new TiO2 GST in Sprague-Dawley rats

Baek HS, Park MK, Kim HM, Im JM, Seo HS, Park HJ, Nah SS

TiO2 nanoparticles are widely used in paints, plastics, cosmetics, printing ink, rubber, food products, pharmaceuticals and other products (photocatalyst, etc.). However, there is little toxicological information during reproduction and developmental...
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Establishment of Neurotoxicity Assessment Using Microelectrode Array (MEA) with hiPSC-Derived Neurons and Evaluation of New Psychoactive Substances (NPS)

Kang Kr, Kim CY, Kim J, Ryu B, Lee SG, Baek J, Kim YJ, Lee JM, Lee Y, Choi SO, Woo DH, Park IH, Chung HM

Background and Objectives: Currently, safety pharmacological tests for the central nervous system depend on animal behavioral analysis. However, due to the subjectivity of behavioral analysis and differences between species, there...
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Comparison of laxative effects of fermented soybeans (Cheonggukjang) containing toxins and biogenic amines against loperamide-induced constipation mouse model

Kim HR, Park IS, Park SB, Yang HJ, Jeong DY, Kim SY

BACKGROUND/OBJECTIVES: (Cheonggukjang) is a traditional fermented soybean paste with significant health-promoting effects. On the other hand, there have been insufficient studies on the safety and efficacy of (Cheonggukjang), which is...
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Hepatotoxic mechanism of diclofenac sodium on broiler chicken revealed by iTRAQ-based proteomics analysis

Sun C, Zhu T, Zhu Y, Li B, Zhang J, Liu Y, Juan C, Yang S, Zhao Z, Wan R, Lin S, Yin B

Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives:...
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Chronological Analysis of Acute Hematological Outcomes after Proton and Photon Beam Craniospinal Irradiation in Pediatric Brain Tumors

Yoo GS, Yu JI, Cho S, Han Y, Oh Y, Lim DH, Nam HR, Lee JW, Sung KW, Shin HJ

Purpose This study aimed to compare the early hematological dynamics and acute toxicities between proton beam craniospinal irradiation (PrCSI) and photon beam craniospinal irradiation (PhCSI) for pediatric brain tumors. Materials and Methods...
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Accelerated hypofractionated breast radiotherapy with simultaneous integrated boost: a feasibility study

Yadav BS, Gupta S, Dahiya D, Gupta A, Oinam AS

Purpose: To assess the feasibility of accelerated hypofractionated radiotherapy with simultaneous integrated boost (SIB) in patients with breast cancer. Materials and Methods: A total of 27 patients after breast-conserving surgery were...
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Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats

Ilechukwu I, Ehigiator BE, Ben IO, Okonkwo CJ, Olorunfemi OS, Modo UE, Ilechukwu CE, Ohagwa NJ

Microplastics have become a significant environmental concern. However, information on toxicity of microplastics in terrestrial organisms is limited. In this study, the chronic toxic effects of polystyrene microplastics (PS-MPs) on...
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