J Korean Soc Pediatr Endocrinol.  2009 Jun;14(1):82-84.

A Case of Fulminant Type 1 Diabetes Mellitus with Peripheral Neuropathy in a Korean Child

• Kim MS
• Yu KY
• Lee SY
• Kim SY
• Kim SJ
• Hwang PH
• Lee DY

Abstract

Type 1 diabetes is an insulin-deficient status due to severe destruction of pancreatic beta cells, and is classified into two subtypes, type 1A and type 1B. Type 1A diabetes is autoimmune and type 1B is idiopathic diabetes. Recently fulminant type 1 diabetes has been identified as a new subtype of idiopathic diabetes. It develops rapidly without any evidence of autoimmunity. This subtype of type 1 diabetes was firstly introduced by Imagawa et al. in 2000, and exclusively reported in Japan. Nonetheless, there has been no case reported in Korea till now. Here, we report a case of fulminant type 1 diabetes in 14-year-old girl. She had acute symptoms for short duration, negative islet-related autoantibodies, elevated serum levels of pancreatic exocrine enzymes (amylase, lipase), high blood glucose level and peripheral neuropathy. But HbA1c level was in normal range. Treatment with insulin was successful, acute symptoms were improved and abnormal laboratory data normalized. Her recent HbA1c level showed only a mild elevation.

Keyword

Diabetes Mellitus; Type 1; Diabetic Neuropathy; Child

MeSH Terms

Adolescent
Autoantibodies
Autoimmunity
Blood Glucose
Child
Diabetes Mellitus
Diabetes Mellitus, Type 1
Diabetic Neuropathies
Humans
Insulin
Insulin-Secreting Cells
Japan
Korea
Peripheral Nervous System Diseases
Reference Values
Autoantibodies
Blood Glucose
Insulin