J Obes Metab Syndr.  2017 Jun;26(2):147-150. 10.7570/jomes.2017.26.2.147.

A Case of Fulminant Type 1 Diabetes in a Patient with Type 2 Diabetes Mellitus

• Kim JM
• Han JH
• Joung KH
• Lee JH
• Kim HJ
• Ku BJ

• KMID: 2387488
• DOI: http://doi.org/10.7570/jomes.2017.26.2.147

Abstract

Fulminant type 1 diabetes mellitus is a recently identified subtype of type 1 diabetes characterized by abrupt disease onset, a very short (<1 week) duration of diabetic symptoms, acidosis at diagnosis, negative status of islet-related autoantibodies, and virtually no C-peptide secretion. Cases of fulminant type 1 diabetes are prominently observed in East Asia, with several case reports and studies having originated from Japan. Indeed, a recent study from Japan reported that fulminant type 1 diabetes accounts for 15-20% of type 1 diabetes cases associated with onset of ketosis or ketoacidosis. Since 2005, several fulminant type 1 diabetes cases have also been reported in South Korea; however, there have been no reports of cases in patients previously diagnosed with type 2 diabetes mellitus. Here, we report a rare case of fulminant type 1 diabetes in a patient previously diagnosed with type 2 diabetes.

Keyword

Diabetes mellitus type 1; Diabetic ketoacidosis; Diabetes mellitus type 2

MeSH Terms

Acidosis
Autoantibodies
C-Peptide
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2*
Diabetic Ketoacidosis
Diagnosis
Far East
Humans
Japan
Ketosis
Korea
Autoantibodies
C-Peptide