Korean J Med.  2006 Mar;70(3):342-346.

A case of fulminant type 1 diabetes mellitus

• Rhee SY
• Chon S
• Koh G
• Oh S
• Woo JT
• Kim JW
• Kim YS

Abstract

A novel subtype of type 1B diabetes with rapid onset and no evidence of autoimmunity has been recently proposed as fulminant type 1 diabetes. The pathogenesis of fulminant type 1 diabetes has not been fully understood. We report a case of fulminant type 1 diabetes with diabetic ketoacidosis. A 31-year-old male was referred to our hospital because of high plasma glucose level and acidosis. Laboratory findings were rendering a diagnostic picture of diabetic ketoacidosis with acute renal insufficiency. While there was high plasma glucose, normal HbA1c and other laboratory findings suggested a very recent onset of diabetes mellitus. A test to detect antibodies to islet cell antigen IA-2 was negative, but those of glutamic acid decarboxylase (GAD) was weakly positive. The patient successfully recovered without any serious complication after fluid and insulin based management.

Keyword

Diabetes mellitus; Type 1

MeSH Terms

Acidosis
Acute Kidney Injury
Adult
Antibodies
Autoimmunity
Blood Glucose
Diabetes Mellitus
Diabetes Mellitus, Type 1*
Diabetic Ketoacidosis
Glutamate Decarboxylase
Humans
Insulin
Islets of Langerhans
Male
Antibodies
Glutamate Decarboxylase
Insulin