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Diabetic Peripheral Neuropathy as a Risk Factor for Sarcopenia

Oh TJ, Song Y, Moon JH, Choi SH, Jang HC

BACKGROUND: Diabetic peripheral neuropathy (DPN) is prevalent in patients with type 2 diabetes, and its prevalence increases with age. A previous study demonstrated the association between DPN and muscle dysfunction;...
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Self-Care of Diabetic Nephropathy

Shin UJ

Early intervention in patients with diabetes may slow the progression of kidney disease, and early recognition of renal impairment is critical to achieving optimal patient outcomes. Annual screening for the...
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Acute cardiovascular complications in patients with diabetes and hypertension: management consideration for minor oral surgery

Jadhav AN, Tarte PR

OBJECTIVES: Medically compromised patients often fear required dental surgical procedures that can increase the risk of medical emergency when combined with reduced tolerance for stress. A stress reduction protocol (SRP)...
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Association between Body Fat and Diabetic Peripheral Neuropathy in Middle-Aged Adults with Type 2 Diabetes Mellitus: A Preliminary Report

Oh TJ, Lee JE, Choi SH, Jang HC

BACKGROUND: Previous epidemiologic studies showed that obesity increased the risk of diabetic peripheral neuropathy (DPN). However, there is very limited data about the impact of body fat measured by body...
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Treatment Strategies for Diabetic Neuropathy

Oh J

The most prevalent microvascular complication of diabetes mellitus is neuropathy, which encompasses distal symmetric polyneuropathy, mononeuropathy, radiculoplexopathy, and autonomic neuropathy. Intensive glucose control prevents and effectively halts the progression of...
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Clinical Evaluation for Diabetic Neuropathy

Sohn EH

Diabetic polyneuropathy (DPN) causes neuropathic pain with reduced quality of life as well as diabetic foot ulceration which sometimes resulted in amputation. Early detection and improved knowledge of pathogenic pathways...
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Diabetic Neuropathy: Classification and Pathogenesis

Yoon BN

This article provides an overview for understanding the classification and pathogenesis of diabetic neuropathy. Diabetic neuropathies are prevalent disorder. The most common manifestation is distal symmetric polyneuropathy, but various patterns...
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Effects of Repetitive High Frequency Motor Cortex Transcranial Magnetic Stimulation and Cortical Disinhibition in Diabetic Patients with Neuropathic Pain: A Case Control Study

Han Y, Lee CH, Min KW, Han KA, Choi HS, Kang YJ

OBJECTIVE: To investigate the cortical disinhibition in diabetic patients with neuropathic pain and without pain. In addition, we assessed the cortical disinhibition and pain relief after repetitive transcranial magnetic stimulation...
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Time-Dependent Changes of Urethral Function in Diabetes Mellitus: A Review

Cao N, Gu B, Gotoh D, Yoshimura

This article reviewed the current knowledge on time-course manifestation of diabetic urethral dysfunction (DUD), and explored an early intervention target to prevent the contribution of DUD to the progression of...
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Diabetic Neuropathic Cachexia in a Young Woman

Yusof NA, Idris NS, Zin FM

Profound weight loss with painful symmetrical peripheral neuropathy in diabetic patients was first described as diabetic neuropathic cachexia more than 4 decades ago. It is a distinct type of diabetic...
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Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-Methyl-D-Aspartate Receptors

Ismail CA, Suppian R, Abd Aziz C, Haris K, Long I

BACKGROUND: This study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli. METHODS: Thirty-two Sprague-Dawley male rats were randomly...
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Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet

Spallone V

The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for...
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Optimal Ultrasonographic Measurements for Diagnosing Carpal Tunnel Syndrome in Patients With Diabetic Sensorimotor Polyneuropathy: A Case-Control Study

Park JW, Lee S, Jang RW, Lee S, Lee S, Cho H, Choi YH, Kwak J

OBJECTIVE: To investigate the optimal sonographic method for diagnosing carpal tunnel syndrome (CTS) in patients with diabetic sensorimotor polyneuropathy (DSP). METHODS: A total of 190 participants were divided into four groups...
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7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress

Cho SJ, Kang KA, Piao MJ, Ryu YS, Fernando P, Zhen AX, Hyun YJ, Ahn MJ, Kang HK, Hyun JW

Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent...
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Patterns of Nerve Conduction Abnormalities in Patients with Type 2 Diabetes Mellitus According to the Clinical Phenotype Determined by the Current Perception Threshold

Park JH, Won JC

BACKGROUND: Clinical manifestations of diabetic peripheral neuropathy (DPN) vary along the course of nerve damage. Nerve conduction studies (NCS) have been suggested as a way to confirm diagnoses of DPN,...
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Cardiovascular Autonomic Neuropathy Predicts Higher HbA1c Variability in Subjects with Type 2 Diabetes Mellitus

Yang Y, Lee EY, Cho JH, Park YM, Ko SH, Yoon KH, Kang MI, Cha BY, Lee SH

BACKGROUND: This study aimed to investigate the association between the presence and severity of cardiovascular autonomic neuropathy (CAN) and development of long-term glucose fluctuation in subjects with type 2 diabetes...
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Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects

Lee HJ, Seo HI, Cha HY, Yang YJ, Kwon SH, Yang SJ

Blood glucose homeostasis is well maintained by coordinated control of various hormones including insulin and glucagon as well as cytokines under normal conditions. However, chronic exposure to diabetic environment with...
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The Necessity of the Simple Tests for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients without Neuropathic Symptoms in Clinical Practice

Park JH, Kim DS

Early recognition and appropriate management of diabetic peripheral polyneuropathy (DPNP) is important. We evaluated the necessity of simple, non-invasive tests for DPNP detection in clinical practice. We enrolled 136 randomly-chosen...
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Therapeutic alternatives in painful diabetic neuropathy: a meta-analysis of randomized controlled trials

Vilar S, Castillo J, Munuera Martínez PV, Reina M, Pabón M

BACKGROUND: One of the most frequent problems caused by diabetes is the so called painful diabetic neuropathy. This condition can be treated through numerous types of therapy. The purpose of...
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Diagnosis and Management of Diabetic Foot

Lee CW

Diabetic foot is one of the most significant and serious complications of diabetes, and is defined as the foot of diabetic patients with ulceration, infection and/or destruction of the deep...
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