Korean J Intern Med.  2005 Sep;20(3):232-236. 10.3904/kjim.2005.20.3.232.

Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma

• Oh JM
• Kim SH
• Suh CH
• Nahm DH
• Park HS
• Lee YM
• Lee JH
• Park CS
• Shin HD

• KMID: 1782235
• DOI: http://doi.org/10.3904/kjim.2005.20.3.232

Abstract

BACKGROUND
Glutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be associated with asthma related phenotypes such as atopy and bronchial hyperresponsiveness. Therefore we investigated whether this polymorphism may be associated with the development of aspirin-intolerant asthma (AIA). METHODS: GSTP1 Ile105Val polymorphism was determined using a single based extension method in 88 AIA subjects and compared to 154 aspirin-tolerant asthma (ATA) subjects and 119 normal healthy controls (NC) recruited from the Korean population. RESULTS: No significant differences in allele and genotype frequencies of the GSTP1 Ilel105Val polymorphism were observed in the three groups (p> 0.05). However, minor G allele frequency of the GSTP1 Ilel105Val polymorphism in AIA group (16.5%) tended to be lower than in the NC group (20.6%). CONCLUSION: These results suggest a lack of association of the GSTPI Ilel105Val gene polymorphism with AIA phenotype in the Korean population [word count: 159].

Keyword

Aspirin-intolerant asthma; Hyperresponsiveness; Glutathione-S-transferase

MeSH Terms

Polymorphism, Restriction Fragment Length
Polymorphism, Genetic
Male
Korea
Isoenzymes/*genetics
Humans
Glutathione S-Transferase pi/*genetics/*metabolism
Glutathione/*metabolism
Genotype
Female
Case-Control Studies
Asthma/*chemically induced/enzymology/*genetics
Aspirin/*adverse effects
Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
Alleles
Adult