J Korean Med Sci.  2012 Sep;27(9):1098-1104. 10.3346/jkms.2012.27.9.1098.

Salivary Bisphenol-A Levels due to Dental Sealant/Resin: A Case-Control Study in Korean Children

• Han DH
• Kim MJ
• Jun EJ
• Kim JB

• KMID: 1782146
• DOI: http://doi.org/10.3346/jkms.2012.27.9.1098

Abstract

Dental sealants and composite filling materials containing bisphenol-A (BPA) derivatives are increasingly used in children. The aim of this study was to evaluate the association between salivary BPA and the number of tooth surfaces filled with dental sealant, and to determine a cutoff BPA level. Salivary BPA concentration and the number of tooth surfaces filled with dental sealant/resin were determined in 124 age and gender matched children: 62 controls had no dental sealant/resin on their tooth surfaces and 62 cases had more than 4 tooth surfaces with dental sealant/resin. Analysis of covariance (ANCOVA) and conditional logistic regression were performed after controlling for age, gender, salivary flow rate, salivary buffer capacity, frequency of snacking, and frequency of tooth brushing. Salivary BPA levels were 0.002 to 8.305 microg/L. The BPA level of control (0.40 microg/L) was significantly lower than that of case (0.92 microg/L) after controlling for confounders (P = 0.026). Although the 90th BPA percentile had an adjusted OR of 4.58 (95% CI 1.04-20.26, P = 0.045), the significance disappeared in the conditional logistic model. There may be a relationship between salivary BPA level and dental sealant/resin.

Keyword

Bisphenol-A; Epidemiology; Resin; Saliva; Sealant

MeSH Terms

Adolescent
Analysis of Variance
Asian Continental Ancestry Group
Benzhydryl Compounds/*analysis
Case-Control Studies
Child
Enzyme-Linked Immunosorbent Assay
Female
Humans
Logistic Models
Male
Odds Ratio
Phenols/*analysis
Pit and Fissure Sealants/*chemistry
Republic of Korea
Resins, Synthetic/*chemistry
Saliva/*chemistry
Snacks
Benzhydryl Compounds
Phenols
Pit and Fissure Sealants
Resins, Synthetic

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