Gut Liver.
2014 Jan;8(1):13-23.
The Expression of Multiple Proteins as Prognostic Factors in Colorectal Cancer: Cathepsin D, p53, COX-2, Epidermal Growth Factor Receptor, C-erbB-2, and Ki-67
- Affiliations
-
- 1Department of Surgery, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. cmcgslee@catholic.ac.kr
- 2Department of Biostatistics and Computing, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 4Department of Surgery, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea.
- 5Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND/AIMS
A single gene mutation alone cannot explain the poor prognosis of colorectal cancer. This study aimed to establish a correlation between the expression of six proteins and the prognosis of colorectal cancer patients.
METHODS
Tissue samples were collected from 266 patients who underwent surgery for colorectal cancer at our institution from January 2006 to December 2007. The expression of six proteins were determined using immunohistochemical staining of specimens.
RESULTS
Cathepsin D, p53, COX-2, epidermal growth factor receptor, c-erbB-2, and Ki-67 expression were detected in 38.7%, 60.9%, 37.6%, 35.7%, 30.1%, and 74.4% of the samples, respectively. The expression of cathepsin D was significantly correlated with reduced cancer-free survival (p=0.036) and colorectal cancer-specific survival (p=0.003), but the other expression levels were not. In a multivariate analysis, cathepsin D expression was found to be an independent prognostic factor for poorer colorectal cancer-specific survival (hazard ratio, 8.55; 95% confidence interval, 1.07 to 68.49). Furthermore, patients with tumors expressing four or more of the proteins had a significantly decreased cancer-free survival rate (p=0.006) and colorectal cancer-specific survival rate (p=0.002).
CONCLUSIONS
Patients with cathepsin D positivity had a poorer outcome than patients who were cathepsin D-negative. Thus, cathepsin D may provide an indicator for appropriate intensive follow-up and adjuvant chemotherapy.
MeSH Terms
-
Adenocarcinoma/*pathology
Adenocarcinoma, Mucinous/pathology
Adult
Aged
Cathepsin D/analysis
Colorectal Neoplasms/*pathology
Cyclooxygenase 2/analysis
Female
Humans
Ki-67 Antigen/analysis
Male
Middle Aged
Prognosis
Receptor, Epidermal Growth Factor/analysis
Receptor, ErbB-2/analysis
Survival Analysis
Tumor Markers, Biological/*analysis
Tumor Suppressor Protein p53/analysis
Ki-67 Antigen
Cathepsin D
Cyclooxygenase 2
Receptor, Epidermal Growth Factor
Receptor, ErbB-2
Tumor Markers, Biological
Tumor Suppressor Protein p53
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