J Korean Soc Coloproctol.
2009 Apr;25(2):107-112.
Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer
- Affiliations
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- 1Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea. drkhr@chonnam.ac.kr
Abstract
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This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer. METHODS: Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined. Results were correlated with clinical and pathological parameters. RESULTS: Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables. Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009). CONCLUSIONS: Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.
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