Korean Circ J.  2004 May;34(5):435-440. 10.4070/kcj.2004.34.5.435.

Stem Cells for Cardiovascular Disease

Affiliations
  • 1Division of Cardiology, Cardiovascular Center, Korea University Medical Center, Seoul, Korea.

Abstract

Adult stem cells, when exposed to new environments, are remarkably plastic in their developmental potential. Bone marrow stem cells provide a promising therapy in the restoration of myocardial infarction and prevent post infarct congestive heart failure, as there is evidence that cells, such as mesenchymal stem, hematopoietic stem and multipotent adult progenitor, can generate new cardiomyocytes in animals and humans. This review summarizes stem cell therapy for cardiac regeneration after myocardial infarction, including a brief overview of ongoing clinical trials, and outlines the scientific and clinical hurdles that need to be overcome before this therapy can be fully used clinically.

Keyword

Myocardial infarction; Stem cell; Adverse effects; Differentiation; Mechanism; Delivery

MeSH Terms

Adult
Adult Stem Cells
Animals
Bone Marrow
Cardiovascular Diseases*
Heart Failure
Humans
Myocardial Infarction
Myocytes, Cardiac
Plastics
Regeneration
Stem Cells*
Plastics
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