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Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells

Ha S, Jeong SH, Yi K, Chu JJ, Kim S, Kim EK, Yu SW

Neural stem cells (NSCs) have the ability to self-renew and differentiate into neurons, oligodendrocytes, and astrocytes. Highly dynamic nature of NSC differentiation requires the intimate involvement of catabolic processes such...
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Current Stem Cell Therapy for Osteoarthritis

Nam Y, Rim YA, Ju JH

Osteoarthritis is a musculoskeletal disease representative of an aging society. As medical conditions are usually complicated in an aging population, osteoarthritis becomes more frequently encountered in the physician's office. There...
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Periodic Methylation Patterns in the Background Mucosa of Gastric Cancer

Kim SW, Oh JH, Kim TH, Kim JS, Hong SJ

BACKGROUND/AIMS: Gastrointestinal glandular stem cells renew every 8 years. New stem cells with impeded housekeeping gene methylation have unstable phenotypes and are prone to transform into malignant cells. Age-related changes...
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Adult Stem Cells: Beyond Regenerative Tool, More as a Bio-Marker in Obesity and Diabetes

Sen S

Obesity, diabetes, and cardiovascular diseases are increasing rapidly worldwide and it is therefore important to know the effect of exercise and medications for diabetes and obesity on adult stem cells....
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Adult Stem Cells in Hibernation: Future Perspectives of Space Travel

Chen YC, Aui SP, Lai YS, Chang KT

Space traveling is imperative for mankind in the future. Expectedly, hibernation will become an option for space traveler to overcome the endless voyage. With regard to some of the studies...
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Stem cell therapy in pain medicine

Han YH, Kim KH, Abdi S, Kim TK

Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or...
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Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function

Moon J, Kim HR, Shin MG

Mitochondria are the powerhouses of the cell as well as the primary site of hematopoiesis, which also occurs in the cytoplasm. Hematopoietic stem cells (HSCs) are characterized by a very...
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Adult Stem Cell Treatment for Rheumatoid Arthritis

Jung SY

Since methotrexate began to be used in the treatment of rheumatoid arthritis (RA) 30 years ago, RA treatments have advanced rapidly from only reducing joint pain and inflammation to suppressing...
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For Better Fat Graft Outcome in Soft Tissue Augmentation: Systematic Review and Meta-Analysis

Kim JB, Jin HB, Son JH, Chung JH

BACKGROUND: Autologous fat grafts are widely used in plastic surgery, but they have the disadvantage of unpredictability due to variable resorption. This meta-analysis examined the literature on the survival rate...
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Effects of Human Adipose-Derived Stem Cells on the Survival of Rabbit Ear Composite Grafts

Kim CM, Oh JH, Jeon YR, Kang EH, Lew DH

BACKGROUND: Composite grafts are frequently used for facial reconstruction. However, the unpredictability of the results and difficulties with large defects are disadvantages. Adipose-derived stem cells (ADSCs) express several cytokines, and...
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Mesenchymal Stem Cell-Based Therapies against Podocyte Damage in Diabetic Nephropathy

Khalilpourfarshbafi M, Hajiaghaalipour F, Krishnan Selvarajan K, Adam A

Injury to podocytes is an early event in diabetic nephropathy leading to proteinuria with possible progression to end-stage renal failure. The podocytes are unique and highly specialized cells that cover...
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Methods of Isolation and Characterization of Stem Cells from Different Regions of Oral Cavity Using Markers: A Systematic Review

Avinash K, Malaippan , Dooraiswamy JN

BACKGROUND: Periodontitis is a destructive inflammatory disorder of the periodontium caused by the destruction of periodontal tissues namely the PDL, cementum, alveolar bone, and gingiva. Once these tissues are lost,...
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Adult Stem Cells of Orofacial Origin: Current Knowledge and Limitation and Future Trend in Regenerative Medicine

Ebrahimi M, Botelho M

Stem cell research is one of the most rapidly expanding field of medicine which provides significant opportunities for therapeutic and regenerative applications. Different types of stem cells have been isolated...
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Endogenous Stem Cells in Homeostasis and Aging

Lim JE, Son Y

In almost all human tissues and organs, adult stem cells or tissue stem cells are present in a unique location, the so-called stem cell niche or its equivalent, continuously replenishing...
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Proteomic Analysis of Human Adipose Derived Stem Cells during Small Molecule Chemical Stimulated Pre-neuronal Differentiation

Santos J, Milthorpe , Herbert BR, Padula MP

BACKGROUND: Adipose derived stem cells (ADSCs) are acquired from abdominal liposuction yielding a thousand fold more stem cells per millilitre than those from bone marrow. A large research void exists...
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Generation of Insulin-Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD

Lee SH, Rhee M, Kim JW, Yoon KH

BACKGROUND: To develop surrogate insulin-producing cells for diabetes therapy, adult stem cells have been identified in various tissues and studied for their conversion into β-cells. Pancreatic progenitor cells are derived...
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Adult Stem Cell Therapy for Stroke: Challenges and Progress

Bang OY, Kim EH, Cha JM, Moon GJ

Stroke is one of the leading causes of death and physical disability among adults. It has been 15 years since clinical trials of stem cell therapy in patients with stroke...
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Method-Isolation and Culture of Primary Rat Adipose Derived Stem Cells Using Porous Biopolymer Microcarriers

Jin GZ, Park JH, Wall I, Kim HW

Adipose-derived stem cells (ADSCs) are an attractive source of material for mesenchymal stem cell research due to the abundance of adipose and relative ease of access compared with bone marrow....
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Genetically Engineered In Vitro Erythropoiesis

Geiler C, Andrade I, Clayton A, Greenwald

BACKGROUND: Engineered blood has the greatest potential to combat a predicted future shortfall in the US blood supply for transfusion treatments. Engineered blood produced from hematopoietic stem cell (HSC) derived...
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Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women

Kim SY, Kim SK, Lee JR, Woodruff T

As the number of young cancer survivors increases, quality of life after cancer treatment is becoming an ever more important consideration. According to a report from the American Cancer Society,...
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