Gut Liver.  2009 Mar;3(1):41-47.

Cytapheresis in Patients with Severe Ulcerative Colitis after Failure of Intravenous Corticosteroid: A Long-Term Retrospective Cohort Study

• Fukunaga K
• Nagase K
• Kusaka T
• Hida N
• Ohda Y
• Yoshida K
• Tozawa K
• Kamikozuru K
• Iimuro M
• Nakamura S
• Miwa H
• Matsumoto

Abstract

BACKGROUND/AIMS
Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid.
METHODS
Forty-seven UC patients who had received CAP therapy for the first time within 1 year after UC diagnosis were followed for 36 months. One of the inclusion criteria was a clinical activity index (CAI) of > or =7 points at the end of a 2-week iv course of corticosteroid therapy. CAP therapy consisted of ten sessions over 10 weeks.
RESULTS
CAP induced clinical remission (CAI< or =4) in 70.2% patients (33/47). The number of submissions for colectomy was higher for severe UC at entry (CAI> or =12, n=25) than for moderately severe UC at entry (7< or =CAI<12, p=15; p<0.02). The cumulative rates of avoiding surgery and relapse were 54.5% and 24.2%, respectively, at 36 months in patients who responded to CAP therapy. This was similar to that of iv cyclosporine reported recently.
CONCLUSIONS
This study suggest that CAP is an effective therapy in patients who are refractory to conventional medications including iv corticosteroid. Increased remission rates should be expected in refractory patients with moderately severe UC.

Keyword

Inflammatory bowel disease; Corticosteroid; Ulcerative colitis; Leukapheresis

MeSH Terms

Cohort Studies
Colectomy
Colitis, Ulcerative
Cyclosporine
Cytapheresis
Humans
Inflammatory Bowel Diseases
Leukapheresis
Recurrence
Retrospective Studies
Ulcer
Cyclosporine