- Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases
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Oshima T, Miwa H
- KMID: 2517542
- J Neurogastroenterol Motil.
- 2021 Jul;27(3):443.
- doi: 10.5056/jnm18029A
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- When Will My Esophagus Be Fixed?
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Li ZL, Miwa H
- KMID: 2325784
- J Neurogastroenterol Motil.
- 2013 Apr;19(2):124-125.
No abstract available. -
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- Is a Patient With Asymptomatic Esophagitis Really Hyposensitive to Acid and Distention?
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Yamasaki T, Watari J, Oshima T, Tomita T, Miwa H
- KMID: 2325824
- J Neurogastroenterol Motil.
- 2011 Jul;17(3):318-319.
No abstract available. -
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- Do Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Really Have No Effect on the Gastric Emptying Rate?
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Tomita T, Miwa H
- KMID: 2325851
- J Neurogastroenterol Motil.
- 2011 Oct;17(4):434-434.
No abstract available. -
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- Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Helicobacter pylori Eradication and Aspirin
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Watari J, Tomita T, Tozawa K, Oshima T, Fukui H, Miwa H
- KMID: 2500531
- Gut Liver.
- 2020 May;14(3):.
- doi: 10.5009/gnl19079
Whether Helicobacter pylori eradication actually reduces the risk of metachronous gastric cancer (MGC) development remains a controversial question. In this review, we addressed this topic by reviewing the results of... -
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- Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders
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Fukui H, Xu X, Miwa H
- KMID: 2417381
- J Neurogastroenterol Motil.
- 2018 Jul;24(3):367-386.
- doi: 10.5056/jnm18071
Gut microbiota exert a pivotal influence on various functions including gastrointestinal (GI) motility, metabolism, nutrition, immunity, and the neuroendocrine system in the host. These effects are mediated by not only... -
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- Laparoscopic Resection of a Jejunal Inflammatory Fibroid Polyp that Caused Occult Gastrointestinal Bleeding, Diagnosed via Capsule Endoscopy and Double-Balloon Enteroscopy: A Case Report
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Kameda C, Miwa H, Kawabata R, Marukawa D, Murakami M, Noura S, Shimizu J, Hasegawa J
- KMID: 2419712
- Clin Endosc.
- 2018 Jul;51(4):384-387.
- doi: 10.5946/ce.2017.162
An inflammatory fibroid polyp (IFP) is a mesenchymal tumor of the gastrointestinal tract. IFPs in the small intestine are the most frequently detected with symptoms, such as abdominal pain and... -
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- Esophageal Sensation and Esophageal Hypersensitivity: Overview From Bench to Bedside
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Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J
- KMID: 2204231
- J Neurogastroenterol Motil.
- 2010 Oct;16(4):353-362.
Noxious stimuli in the esophagus activate nociceptive receptors on esophageal mucosa, such as transient receptor potential, acid-sensing ion channel and the P2X family, a family of ligand-gated ion channels responsive... -
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- Analysis of the Gastrointestinal Symptoms of Uninvestigated Dyspepsia and Irritable Bowel Syndrome
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Hori K, Matsumoto , Miwa H
- KMID: 2284062
- Gut Liver.
- 2009 Sep;3(3):192-196.
BACKGROUND/AIMS: Epidemiological studies suggest that there is a considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). The aim of this study was to examine concurrent gastrointestinal symptoms... -
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- Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World
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Oshima T, Miwa H
- KMID: 2433471
- J Neurogastroenterol Motil.
- 2015 Jul;21(3):320-329.
- doi: 10.5056/jnm14165
Functional gastrointestinal disorders (FGIDs), represented by functional dyspepsia (FD) and irritable bowel syndrome (IBS), are a group of disorders that include variable combinations of chronic or recurrent gastrointestinal symptoms not... -
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- Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey
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Tamura A, Tomita T, Oshima T, Toyoshima , Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ikehara H, Ohda Y, Fukui H, Watari J, Miwa H
- KMID: 2433461
- J Neurogastroenterol Motil.
- 2016 Oct;22(4):677-685.
- doi: 10.5056/jnm15187
BACKGROUND/AIMS: Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) to investigate defecation habits... -
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- Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia
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Duan S, Imamura N, Kondo T, Kanda H, Kogure Y, Okugawa T, Fukushima M, Tomita T, Oshima T, Fukui H, Noguchi K, Dai Y, Miwa H
- KMID: 2528040
- J Neurogastroenterol Motil.
- 2022 Apr;28(2):255-264.
- doi: 10.5056/jnm21204
Background/Aims Herbal medicine is an important complementary therapy for functional dyspepsia (FD). However, its effect against gastric hypersensitivity in patients with FD has rarely been evaluated. Yokukansan (YKS), a traditional Japanese... -
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- Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry
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Yamasaki T, Tomita T, Mori S, Takimoto M, Tamura A, Hara K, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H
- KMID: 2417384
- J Neurogastroenterol Motil.
- 2018 Jul;24(3):403-409.
- doi: 10.5056/jnm17147
BACKGROUND/AIMS: High-resolution esophageal manometry (HREM) is considered to be the gold standard for the diagnosis of achalasia. However, the Japan Esophageal Society recommends that esophagography is also accurate in either... -
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- Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia
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Asano H, Tomita T, Nakamura K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Fukushima , Hirota S, Watari J, Miwa H
- KMID: 2387830
- J Neurogastroenterol Motil.
- 2017 Jul;23(3):392-399.
- doi: 10.5056/jnm16173
BACKGROUND/AIMS: Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of... -
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- Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases
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Oshima T, Miwa H
- KMID: 2417378
- J Neurogastroenterol Motil.
- 2018 Jul;24(3):334-344.
- doi: 10.5056/jnm18029
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, they have a number of limitations including slow onset of action, influence by... -
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- Diarrhea-predominant Irritable Bowel Syndrome-like Symptoms in Patients With Quiescent Crohn’s Disease: Comprehensive Analysis of Clinical Features and Intestinal Environment Including the Gut Microbiome, Organic Acids, and Intestinal Permeability
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Tomita T, Fukui H, Morishita D, Maeda A, Makizaki Y, Tanaka Y, Ohno H, Oshima T, Miwa H
- KMID: 2537945
- J Neurogastroenterol Motil.
- 2023 Jan;29(1):102-112.
- doi: 10.5056/jnm22027
Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms frequently occur in patients with quiescent Crohn’s disease (CD). To investigate the factors underlying IBS-D-like symptoms in patients with quiescent CD, we performed a... -
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- Cytapheresis in Patients with Severe Ulcerative Colitis after Failure of Intravenous Corticosteroid: A Long-Term Retrospective Cohort Study
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Fukunaga K, Nagase K, Kusaka T, Hida N, Ohda Y, Yoshida K, Tozawa K, Kamikozuru K, Iimuro M, Nakamura S, Miwa H, Matsumoto
- KMID: 1744239
- Gut Liver.
- 2009 Mar;3(1):41-47.
BACKGROUND/AIMS: Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study... -
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- Adsorptive Granulocyte/Monocyte Apheresis for the Maintenance of Remission in Patients with Ulcerative Colitis: A Prospective Randomized, Double Blind, Sham-Controlled Clinical Trial
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Fukunaga K, Yokoyama Y, Kamokozuru K, Nagase K, Nakamura S, Miwa H, Matsumoto
- KMID: 2167411
- Gut Liver.
- 2012 Oct;6(4):427-433.
BACKGROUND/AIMS: Weekly granulocyte/monocyte adsorption (GMA) to deplete elevated and activated leucocytes should serve as a non-pharmacological intervention to induce remission in patients with ulcerative colitis (UC). This trial assessed the... -
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- Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals
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Yamasaki T, Tomita T, Takimoto M, Kondo T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H
- KMID: 2395420
- J Neurogastroenterol Motil.
- 2017 Oct;23(4):526-532.
- doi: 10.5056/jnm17067
BACKGROUND/AIMS: When a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However,... -
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- A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation
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Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H
- KMID: 2460486
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):563-575.
- doi: 10.5056/jnm18194
BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic... -
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