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Clinical Experiences of Therapeutic Leukapheresis

Han KS, Lee YK

  • KMID: 1932266
  • Korean J Blood Transfus.
  • 1996 Jun;7(1):57-63.
Therapeutic leukapheresis is a treatment modality which selectively remove abnormal leukocytes and relieve symptoms produced by abnormally high concentration of leukocytes in the blood stream. Authors report the experiences of...
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Effect of Leukapheresis on Gene Expression Profiles of Donor's Peripheral Blood Mononuclear Cells

Shin JW, Jin P, Stroncek D

BACKGROUND: Leukapheresis has commonly been used to obtain the cell products intended for clinical cell therapy. Hypocalcemia related to citrate toxicity and some circulatory effects such as hypovolemia and...
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Therapeutic Leukapheresis for the Management of Hyperleukocytosis: Ten-year Experience in a Tertiary Care Hospital

Kim B, Lee K, Kim S, Kim HO

BACKGROUND: Hyperleukocytosis is a medical emergency that is characterized by increased blood viscosity and predisposition to various neurological, pulmonary, and gastrointestinal complications. In addition, patients are at risk of the...
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Therapeutic Leukapheresis for Acute Lymphoblastic Leukemia with Severe Hyperleukocytosis in a Six-Week-Old Infant (4.7 kg)

Byun JY, Shin KM, Won SC, Lyu CJ, Lim HS, Kim HO

  • KMID: 1917300
  • Korean J Pediatr Hematol Oncol.
  • 2002 Oct;9(2):250-254.
We report a 4.7 kg infant who received a therapeutic leukapheresis as an immediate treatment for acute lymphoblastic leukemia with severe hyperleukocytosis. By decreasing the number of circulating white...
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Leukapheresis with high dose hydroxyurea in the management of lower leg artery obstruction in Chronic Myelogenous Leukemia

Lim CS, Lee SO, Kwak JY, Yim CY

  • KMID: 2306355
  • Korean J Med.
  • 1998 Nov;55(5):960-964.
There was no specific criteria of white cell count to determine the therapy of hyperleukocytosis in chronic myelogenous leukemia (CML). Therapeutic leukapheresis usually indicated in acute myelogenous leukemia with over...
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Clinical Effects and Safety of Therapeutic Leukapheresis in Hyperleukocytosis

Lee SN, Kong JH, Eom HS, Lee H, Park HJ, Sohn JY, Kong SY

BACKGROUND: Therapeutic leukapheresis is the cytoreduction procedure performed before chemotherapy in patients with hyperleukocytosis for prevention of complication. However, there have been clinical concerns about bleeding tendency due to anticoagulant...
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Peripheral Blood Stem Cell Harvest by Transient Radial Arterial Catheterization in Pediatric Patients

Lee KH, Kim MK, Hong CH

  • KMID: 2072462
  • Korean J Pediatr Hematol Oncol.
  • 1997 Apr;4(1):126-132.
BACKGROUND: Peripheral blood stem cell transplantation in children has some difficulties compared with adult cases. Despite the children's total blood volume is small, they have a relatively higher volume of...
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Evaluation of therapeutic leukapheresis in hyperleukocytic leukemias

Lee YW, Jeong GY, Koo HH, Lee HG, Kim DW

  • KMID: 2069262
  • Korean J Blood Transfus.
  • 1998 Dec;9(2):219-226.
BACKGROUND: Leukemia with hyperleukocytosis is risk factor for early mortality and morbidity. Therepeutic leukapheresis has been recognized as the choice of treatment modality to prevent leukostatic complications by selective removal...
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Leukapheresis for Collection of Peripheral Blood Stem Cells in Children with Acute Myelocytic Leukemia

Park HJ, Shin HY, Ahn HS

  • KMID: 2083370
  • Korean J Hematol.
  • 1999 May;34(2):215-227.
BACKGROUND: Post remission therapy is one of the most important issues in the treatment of acute myelocytic leukemia (AML). Recently, autologous peripheral blood stem cell transplantation (PBSCT) has become an...
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Peripheral Blood Stem Cell Collection and Engraftment Kinetics in Pediatric Patients

Yoon WS, Kook H, Kim CJ, Park A, Ryang DW, Hwang TJ

  • KMID: 2278189
  • Korean J Pediatr Hematol Oncol.
  • 1999 Oct;6(2):330-338.
PURPOSE: Peripheral blood stem cell transplantation (PBSCT) has recently been used to rescue from myelosuppression following high-dose chemo-radiotherapy in patients with leukemia and solid tumor. Nevertheless, few data are...
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Evaluation of the Collection Efficiency of the Granulocyte in Leukapheresis Using 10% Pentastarch

Lim JB, Kim MJ, Yi KS, Lee SM, Kim HO

  • KMID: 2300518
  • Korean J Clin Pathol.
  • 1999 Feb;19(1):125-130.
BACKGROUND: To collect high concentration of granulocytes for transfusion to neutropenic cancer patients with infections, we investigated the effect of G-CSF or dexamethasone as granulocyte mobilizers and 10% pentastarch (PS)...
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The Analysis of Engraftment Results of Autologous Peripheral Blood Stem Cell Transplantation in Kosin Medical Center in 1999

Hwang HY, Kim MH, Kim YS, Eo WK, Park JS, Jeong SH, Lee CS

  • KMID: 1963107
  • J Clin Pathol Qual Control.
  • 2001 Jun;23(1):185-191.
BACKGROUND: Most transplant groups have established their own guideline to monitor the timing of successful leukapheresis and minimal number of CD34+ cells to ensure engraftment in autologous peripheral blood stem...
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Effect of the G-CSF schedule for harvesting peripheral blood progenitor cells from healthy donors

Lee SE, Park JY, Lee SW, Choi IJ, Lee SJ, Park CW

  • KMID: 2256066
  • Korean J Med.
  • 2008 Nov;75(5):553-558.
BACKGROUND/AIMS: Peripheral blood progenitor cells (PBSC) have been used instead of bone marrow cells for allogeneic transplantation. Progenitor cells are mobilized using granulocyte colony stimulating factor (G-CSF). Kinetic studies of...
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The Correlation between G-CSF Dosage and the Number of Collected CD34+ Cells in Pediatric Patients Undergoing Peripheral Blood Stem Cell Mobilization

Lee JS, Jung HJ, Park JE

BACKGROUND: In high risk malignancies of pediatric patients, many investigators have explored the use of stronger myeloablative regimens with autologous peripheral blood stem cell rescue such as the Tandem protocol....
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Peripheral Blood Stem Cell Collection through Large Volume Leukapheresis after Mobilization with GM-CSF and/or G-CSF in Normal Healthy Donors

Jung JT, Sung WJ, Chae YS, Seo KW, Kwon HE, Park SW, Lee NY, Kwak DS, Kim JG, Sohn SK, Suh JS, Lee KB

  • KMID: 1832120
  • Korean J Hematol.
  • 2001 May;36(2):154-161.
BACKGROUND: The use of colony stimulating factor (CSF) has increased to mobilize hematopoietic progenitor cells for allo-PBSCT. The most effective mobilization regimen has not yet defined. The authors analyzed the...
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Immunophenotypic Analysis of Long-term Culture-Initiating Cells in Long-term Liquid Culture

Ryu KH, Sung KW, Cheong HM, Choi HS, Park HJ, Ahn HS

  • KMID: 2278136
  • Korean J Pediatr Hematol Oncol.
  • 1998 Apr;5(1):130-137.
Purpose: Long-term culture- initiating cells(LTC-IC) are stem cells that have the capacities of long-term engraftment and helping to establish hematopoietic microenvironment. For evaluation of the LTC-IC, we measured the counts...
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Usefulness of Calcium Injection in Large-volume Leukapheresis

Baek HM, Nahm CH, Kim CS, Kim IH, Lee MH

  • KMID: 2089994
  • Korean J Blood Transfus.
  • 2004 Jun;15(1):38-44.
BACKGROUND: Hypocalcemia is the most common side effect in large-volume leukapheresis (LVL) for collection of peripheral blood stem cells (PBSCs). We evaluated the effect of intravenous calcium infusion on the...
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Granulocyte transfusions from G-CSF- and dexamethasone-stimulated healthy donors for treatment of patients with severe neutropenia-related infections

Lee BH, Lee JJ, Kim YK, Cho SH, Shin DH, Cho D, Ryang DW, Park MR, Chung IJ, Kim HJ

  • KMID: 2306045
  • Korean J Med.
  • 2003 Apr;64(4):459-467.
BACKGROUND: Granulocyte transfusions have been used to treat severe, progressive infections in neutropenic patients who fail to respond to antimicrobial agents. Although corticosteroid or granulocyte colony-stimulating factor (G-CSF) were previously...
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High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation in Pediatric Patients with High-risk Neuroblastoma

Kim S, Lee Y, Lyu CJ, Baek EJ, Kim HS, Lee K, Kim HO

  • KMID: 1909659
  • Korean J Blood Transfus.
  • 2007 Dec;18(3):227-238.
BACKGROUND: High dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) has become standard therapy for high-risk neuroblastoma patients. We performed a retrospective analysis to assess the characteristics...
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Preapheresis WBC, mononuclear cell and CD34+ cell counts as predictors of optimal timing of peripheral blood stem cell collection

Kim MJ, Park Q, Lim HS, Kim HO, Min YH, Lyu CJ, Nahm CH

  • KMID: 2253959
  • Korean J Blood Transfus.
  • 1998 Jun;9(1):101-110.
BACKGROUND: Peripheral blood stem cells (PBSC) transplantation has been widely used as a substitute of bone marrow transplantation in patients with hematologic malignancies and solid tumors. Because, PBSC harvest by...
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