J Bacteriol Virol.  2014 Sep;44(3):283-289. 10.4167/jbv.2014.44.3.283.

Regulation of Host Cell Signaling Pathways by Respiratory Syncytial Virus Nonstructural Protein NS1 and NS2

Affiliations
  • 1Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Korea. innks@khu.ac.kr

Abstract

Human Respiratory Syncytial virus (hRSV) is a leading cause of severe lower respiratory tract diseases in the pediatric population.hRSV frequently causes severe morbidity and mortality in high risk groups including infants with congenital heart disease and the immunosuppressed patients. Although hRSV is recognized as a major public health threat and economic burden worldwide, there is no licensed vaccine and effective therapeutic agent. Viral nonstructural (NS) proteins have been known to play multiple functions for efficient viral replication and pathogenesis. Especially, diverse functions of influenza A virus NS1 have been extensively studies. Recent studies demonstrated that NS1 and NS2 of RSV also exert diverse functions to modulate cellular environment and antiviral immune responses. Since NS proteins of RSV are required for efficient replication and pathogenesis, NS mutant viruses have been tested as live-attenuated vaccines. This review will outline the recent progress in understanding the various functions of RSV NS1 and NS2.

Keyword

Respiratory syncytial virus; NS1; NS2; Interferon

MeSH Terms

Heart Defects, Congenital
Humans
Infant
Influenza A virus
Interferons
Mortality
Public Health
Respiratory Syncytial Virus, Human
Respiratory Syncytial Viruses*
Respiratory Tract Diseases
Vaccines
Interferons
Vaccines
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