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Case Report of Erdheim-Chester Disease Successfully Treated with Pegylated Interferon: A Single-Center Experience

Lim Y, Yoon SE, Cho J, Kim D, Jung CW

Erdheim-Chester disease (ECD), also known as non-Langerhans cell histiocytosis, is a multi-systemic disease with unclear pathogenesis. Based on a small number of case studies, pegylated interferon-α (PEG-IFN-α) has been used...
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Immune Responses After Vaccination With Primary 2-Dose ChAdOx1 Plus a Booster of BNT162b2 or Vaccination With Primary 2-Dose BNT162b2 Plus a Booster of BNT162b2 and the Occurrence of Omicron Breakthrough Infection

Choi SH, Park JY, Kweon OJ, Park JH, Kim MC, Lim Y, Chung JW

Background: Before the omicron era, health care workers were usually vaccinated with either the primary 2-dose ChAdOx1 nCoV-19 (Oxford-AstraZeneca) series plus a booster dose of BNT162b2 (Pfizer-BioNTech) (CCB group) or...
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Interferon-gamma release assay has poor diagnostic accuracy in differentiating intestinal tuberculosis from Crohn’s disease in tuberculosis endemic areas

Sachdeva K, Kumar P, Kante B, Vuyyuru SK, Mohta S, Ranjan MK, Singh MK, Verma M, Makharia G, Kedia S, Ahuja V

Background/Aims: Intestinal tuberculosis (ITB) and Crohn’s disease (CD) frequently present with a diagnostic dilemma because of similar presentation. Interferon-gamma release assay (IGRA) has been used in differentiating ITB from CD,...
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Hycanthone Inhibits Inflammasome Activation and Neuroinflammation-Induced Depression-Like Behaviors in Mice

Boo KJ, Gonzales EL, Remonde CG, Seong JY, Jeon SJ, Park YM, Ham BJ, Shin CY

Despite the various medications used in clinics, the efforts to develop more effective treatments for depression continue to increase in the past decades mainly because of the treatment-resistant population, and...
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Changes and correlations of T-cell coinhibitory molecule programmed death-1 and interferon-γ in pediatric immune thrombocytopenia

El-Gendy FM, Shehata AM, El-Kawy EAA, El-Hawy MA

Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by abnormalities of T cells subsets. Programmed death-1 (PD-1) is a co-signaling inhibitory molecule in T cells that is involved...
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Preliminary Study on Natural Killer Cell Activity for Interferon-Gamma Production after Gamma Knife Radiosurgery for Brain Tumors

Park K, Jeong SS, Kim JH, Chung HT, Lee EJ, Moon HE, Park KH, Kim JW, Park HR, Lee JM, Lee HJ, Kim HR, Cho YH, Paek SH

Objective : High-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer...
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The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer

Song IH, Kim YA, Heo SH, Bang WS, Park HS, Choi Yh, Lee H, Seo JH, Cho Y, Jung SW, Kim HJ, Ahn SH, Lee HJ, Gong G

Purpose The expression of major histocompatibility complex class I (MHC I) has previously been reported to be negatively associated with estrogen receptor (ER) expression. Furthermore, MHC I expression, level of tumor-infiltrating...
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A Case of Combination Therapy of IFN-β1b and Mitomycin-C on Recurred Ocular Surface Squamous Neoplasia

Lee JK, Son BK, Jin KH

Purpose: To report a case of combination therapy with interferon β1b (IFN-β1b) and mitomycin-C (MMC) for recurrent ocular surface squamous neoplasia (OSSN). Case summary: A 72-year-old female presented with a white...
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Presumed Latent Tuberculosis-related Intermediate Uveitis Manifesting as Recurrent Vitreous Hemorrhage

Lee JH, Seo YH, Lee EC

Purpose: We report a case of recurrent vitreous hemorrhage in a patient with presumed latent tuberculosis-related intermediate uveitis, and we review the literature. Case summary: A 58-year-old male visited our clinic...
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Three Cases of Erythema Induratum Diagnosed by Histopathology and Interferon-Γ Release Assay

Jung SW, Choi EH

  • KMID: 2526775
  • Korean J Dermatol.
  • 2022 Feb;60(2):115-119.
Erythema induratum (EI) is a tuberculid caused by a hypersensitivity reaction against Mycobacterium tuberculosis or its metabolic products, but it is usually absent in skin lesions. Interferon-γ release assay (IGRA)...
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The Relationship between Systemic Anti-Psoriatic Treatment and Positive Interferon-Gamma Release Assay Rate in Moderate-Severe Korean Psoriasis Patients

Yang SY, Chun EJ, Kim JK, Kim SS, Kim CW

  • KMID: 2525566
  • Korean J Dermatol.
  • 2022 Jan;60(1):1-6.
Background: The relationship between latent tuberculosis and the use of certain biologics is well known, but the relationship between the test for latent tuberculosis results and psoriasis itself or systemic...
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Predictive Value of Positive Interferon-Gamma Release Assay for Hemodialysis Patients: A Cross-Sectional Study in a Tertiary Care Hospital in South Korea

Kim YN, Lee J, Jung Y

Background: Tuberculosis (TB) is a common infectious disease in dialysis patients with profound alterations in immune response. The risk of TB among dialysis patients is important but remains unclear. This...
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Chest Radiographs and CT Findings during Healthcare Workers’ Tuberculosis Screening Using InterferonGamma Release Assay: Retrospective Observational Study

Choi YR, Lee JK, Heo EY, Kim DK, Jin KN

Purpose To investigate the incidence of tuberculosis (TB) in healthcare workers (HCWs) with positive interferon-gamma release assay (IGRA) results based on chest X-ray (CXR) and CT findings and determine the...
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Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia

Park S, Kim HJ, Hwang HS, Han AR

Background and Objectives: The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M),...
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Latent Tuberculosis Infection Screening and Treatment in Congregate Settings (TB FREE COREA): Demographic Profiles of InterferonGamma Release Assay Cohort

Kim HW, Min J, Choi JY, Shin AY, Myong JP, Lee Y, Yim HW, Jeong H, Bae S, Shim E, In H, Chun C, Kim G, Kang JY, Lee SS, Park JS, Kim JS

In 2017, the Korean government launched an unprecedentedly large-scaled latent tuberculosis infection (LTBI) screening project which covered more than a million individuals in congregate settings. A total of 1,047,689 participants...
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Monocytes Contribute to IFN-β Production via the MyD88-Dependent Pathway and Cytotoxic T-Cell Responses against Mucosal Respiratory Syncytial Virus Infection

Kim TH, Kim CW, Oh DS, Jung HE, Lee HK

Respiratory syncytial virus (RSV) is the leading cause of respiratory viral infection in infants and children. However, little is known about the contribution of monocytes to antiviral responses against RSV...
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Clinical Outcomes of Japanese Encephalitis after Combination Treatment of Immunoglobulin, Ribavirin, and Interferon-α2b

Son H, Sunwoo JS, Lee SK, Chu K, Lee ST

Background and Purpose Japanese encephalitis (JE) is caused by the JE virus of the Flaviviridae family and is spread by mosquito bites, and no specific antiviral treatment for it exists....
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Autologous cervical tumor lysate pulsed dendritic cell stimulation followed by cisplatin treatment abrogates FOXP3+ cells in vitro

Dhandapani H, Seetharaman A, Jayakumar H, Ganeshrajah S, Singh SS, Thangarajan R, Ramanathan P

Objective Dendritic cells (DCs) are administered as immunotherapeutic adjuvants after the completion of standard treatment in most settings. However, our Phase I trial indicated that one patient out of four, who...
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Safety and Effectiveness of Cytomegalovirus Specific Antigen Induced Interferon-Gamma ELISPOT/ELISA: A Systematic Review

Choi W, Hahn J, Lee W, Shin C

Background: This study evaluated the safety and effectiveness of the cytomegalovirus (CMV) Specific Antigen Induced Interferon-Gamma ELISPOT (enzyme-linked immunosorbent spot)/ELISA (enzyme-linked immunosorbent assay) procedure in predicting the risk of CMV...
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The Role of STAT1 in T Helper Cell Differentiation during Breast Cancer Progression

Banik S, Rakshit S, Sarkar K

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that facilitate several facets of cellular immunity, proliferation, apoptosis, and differentiation. They are principally...
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