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Current Advances in the Development of Vaccines and Therapeutic Agents Against MERS-coV

Lee NR, Yi CM, Inn KS

Middle East respiratory syndrome (MERS) is an emerging infectious disease caused by the betacoronavirus (MERS-CoV). Since the isolation and identification of MERS-CoV in 2012, cases have been spread to neighboring...
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Sensing DNA Viruses and Bacteria by Intracellular DNA Sensors

Lee NR, Shin HB, Kim HI, Choi MS, Inn KS

The innate immune system confers first-line defense against various pathogens including bacteria and viruses. Early detection of invading pathogens by the host depends on a limited number of specific pattern...
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Regulation of Host Cell Signaling Pathways by Respiratory Syncytial Virus Nonstructural Protein NS1 and NS2

Shin HB, Choi MS, Yi CM, Kim JE, Jo SJ, Kim HI, Lee NR, Inn KS

Human Respiratory Syncytial virus (hRSV) is a leading cause of severe lower respiratory tract diseases in the pediatric population.hRSV frequently causes severe morbidity and mortality in high risk groups including...
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The Role of Sodium-taurocholate Co-transporting Polypeptide as a Receptor during HBV Infection

Kim SY, Jang E, Inn KS

According to World Health Organization, more than 200 million people suffer with chronic hepatitis caused by Hepatitis B virus (HBV) infection worldwide. Chronic hepatitis B causes various complications including liver...
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Synthetic 3′,4′-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model

Kim N, Yoo HS, Ju YJ, Oh MS, Lee KT, Inn KS, Kim NJ, Lee JK

Neuroinflammation is an immune response within the central nervous system against various proinflammatory stimuli. Abnormal activation of this response contributes to neurodegenerative diseases such as Parkinson disease, Alzheimer’s disease, and...
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