Korean J Pathol.  2001 Oct;35(5):440-443.

Small Cell Carcinoma of the Ovary, Hypercalcemic Type, Large Cell Variant

• Lee JS
• Lee JH
• Kim YK
• Park SH
• Ko GH

Abstract

We report the clinical and pathological features, including the immunohistochemical and electron microscopic findings, of a case of hypercalcemic type, large cell variant, ovarian small cell carcinoma. A 44-year-old woman complained of abdominal pain and dysmenorrhea. A mass on the left ovary was detected by computer tomographic scan. A total hysterectomy with bilateral salpingo-oophorectomy was done. Histologically, the tumor was predominantly composed of large cells with abundant eosinophilic cytoplasm and prominent nucleoli. Mucin-containing cells and myxoid stroma were also present. Typical follicle-like spaces with lined by small, closely packed epithelial cells with scanty cytoplasm were occasionally seen. No dense core granules were identified on electron microscopic examination.

Keyword

Ovary; Carcinoma; Small cell; Hypercalcemia

MeSH Terms

Abdominal Pain
Adult
Carcinoma, Small Cell*
Cytoplasm
Dysmenorrhea
Eosinophils
Epithelial Cells
Female
Humans
Hypercalcemia
Hysterectomy
Ovary*