Korean J Med.  2007 May;72(5):563-567.

Primary small cell carcinoma of the ovary and the long-term survival after systemic chemotherapy

• Kim JY
• Kim YJ
• Seong HJ
• Park WY
• Hong YS
• Do YR
• Song HS

Abstract

Ovarian small cell carcinoma is a rare type of ovarian carcinoma with a poor prognosis.The hypercalcemic type is a tumor of unknown histogenesis, and small cell carcinoma of the pulmonary type may be a component of a typical ovarian surface epithelial-stromal tumor. We experienced a case of primary ovarian small cell carcinoma and lung metastasis. The patient was a 65-year old woman who complained of rectal heaviness. The chest x-ray and chest CT scan revealed multiple pulmonary metastases. Abdominal MRI showed a well defined heterogenous solid mass with central necrosis arising from the right ovary and hydronephrosis of the right kidney. Biopsy of the ovarian mass showed small cell carcinoma of the pulmonary type. After 4 cycles of cisplatin (80 mg/m2, on day 1, iv), etoposide (100 mg/m2, on day 1 to 3, iv), the patient achieved a complete response. The follow up chest CT scan 5 years after treatment revealed no evidence of disease. We report here in a case of primary small cell carcinoma of the ovary with lung metastasis and we include a review of the literature.

Keyword

Carcinoma; Ovary

MeSH Terms

Aged
Biopsy
Carcinoma, Small Cell*
Cisplatin
Drug Therapy*
Etoposide
Female
Follow-Up Studies
Humans
Hydronephrosis
Kidney
Lung
Magnetic Resonance Imaging
Necrosis
Neoplasm Metastasis
Ovary*
Thorax
Tomography, X-Ray Computed
Cisplatin
Etoposide