Korean J Obstet Gynecol.  2012 Dec;55(12):1015-1019. 10.5468/KJOG.2012.55.12.1015.

Small cell carcinoma, hypercalcemic type of the ovary

• Kim SS
• Seo YJ
• Kim MJ
• Eom HM
• Jeong EJ
• Byun JM
• Kim YN
• Lee KB
• Sung MS
• Kim KT
• Jeong DH

• KMID: 2274217
• DOI: http://doi.org/10.5468/KJOG.2012.55.12.1015

Abstract

The patient was a 22-year-old woman, who presented with abdominal pain and palpable huge mass. The initial investigation by ultrasound examination showed a huge size heterogenous soild mass and then magnetic resonance imaging presented multilobulated, huge solid mass (16x13 cm) with heterogenous enhancement in left ovary. Serum calcium level was slightly elevated (10.6 mg/dL, normal less than 10.4 mg/dL) and cancer antigen 125 level was normal. She underwent a laparotomy and left salpingo-ophorectomy. Grossly, ovary consists of yellowish solid portion but not cystic portion and outer capsule was ruptured focally. The pathologic finding, including immunohistochemical finding, confirmed small cell carcinoma, hypercalcemic type from ovary. Now, She has been treated with adjuvant chemotherapy (cisplatin, adriamycin, etoposide, cyclophophamide). We report this case with brief review of literature.

Keyword

Ovarian cancer; Small cell carcinoma; Hypercalcemic type

MeSH Terms

Abdominal Pain
Calcium
Carcinoma, Small Cell
Chemotherapy, Adjuvant
Doxorubicin
Etoposide
Female
Humans
Laparotomy
Magnetic Resonance Imaging
Ovarian Neoplasms
Ovary
Calcium
Doxorubicin
Etoposide

Figure

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  Fig. 1 Magnetic resonance imaging (MRI). The coronal and sagittal T2-weighted MR images (A, B) show large multilobulated mass with heterogeneous high signal intensity and multifocal necrotic foci. The tumor is not invasion to adjacent organs, just displacement. Engorged tumor supply vascular structure is also detected in central portion (arrow in B).

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  Fig. 2 Macroscopic findings. 18.0×13.0×8.0 cm, multilobulated, predominantly solid tumor.

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  Fig. 3 Histological findings. (A) Mitoticaily active small-sized tumor cells are diffusely infiltrated (H&E, ×200). (B) Tumor cells show enlarged nuclei with scanty cytoplasm (H&E, ×400). (C) Immunohistochemical staining of the tumor showed positive for vimentin (×200).

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