Korean J Pathol.  2000 Nov;34(11):953-956.

Epithelioid Angiomyolipoma of the Kidney: A case report

• Kim YK
• Lee JS
• Chung KH
• Park SH
• Ko GH

Abstract

Angiomyolipoma is considered by many authors to be a hamartoma, occurring in a sporadic form or in association with tuberous sclerosis. This lesion consists of thick walled blood vessels, smooth muscle, and mature adipose tissue in varying amounts. We have experienced a case of the angiomyolipoma composed of monotypic epithelioid cells. The patient was a 69-year-old female. Clinically, there was no evidence of tuberous sclerosis. Microscopically, the tumor was composed of polygonal cells with abundant eosinophilic granular or clear cytoplasm, pleomorphic nuclei, prominent nucleoli, and multinucleated giant cells. The tumor cells showed positive reaction for HMB45, CD68, smooth muscle actin, and S-100, and negative reaction for epithelial membrane antigen, cytokeratin, vimentin, desmin, CD34, estrogen receptor, and progesterone receptor. Ultrastructual analysis showed the presence of glycogen, mitochondria, and other microorganelles in neoplastic cells. Melanosome or premelanosome was not identified.

Keyword

Epithelioid angiomyolipoma; Kidney

MeSH Terms

Actins
Adipose Tissue
Aged
Angiomyolipoma*
Blood Vessels
Cytoplasm
Desmin
Eosinophils
Epithelioid Cells
Estrogens
Female
Giant Cells
Glycogen
Hamartoma
Humans
Keratins
Kidney*
Melanosomes
Mitochondria
Mucin-1
Muscle, Smooth
Receptors, Progesterone
Tuberous Sclerosis
Vimentin
Actins
Desmin
Estrogens
Glycogen
Keratins
Mucin-1
Receptors, Progesterone
Vimentin