Korean J Pathol.
1999 Jan;33(1):8-14.
Loss of Heterozygosity at VHL, FHIT, and p16 Loci in Nonpapillary Renal Cell Carcinoma
- Affiliations
-
- 1Department of Pathology and Cancer Research Institute, The Catholic University of Korea, Seoul 137-701, Korea.
- 2Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.
Abstract
- The objectives of this study were to characterize the alterations of 3p and 9p in sporadic renal cell carcinomas (RCC) and to assess the relationship between the clinical stages or tumor size and the alteration of these chromosomes. Thirty eight archival, paraffin embedded tissue sections from 38 patients with RCC were analyzed for loss of heterozygosity (LOH) at 3p and 9p with 11 microsatellite markers. LOH was detected in 81.6% (31/38) and 37.8% (14/37) at 3p and 9p, respectively. The frequencies of LOH at VHL and FHIT locus were 75.6% and 72.2%, respectively. Twelve cases out of 38 showed LOH at both 9p21 and 3p. The loss of 3p in the samples tested was not related to clinical stages and tumor size, but that of 9p21 was significantly associated with advanced stage and larger tumor size. These results support that 3p deletion, including VHL and FHIT gene, play a critical role in the tumorigenesis of sporadic RCC, especially at early stage, and that 9p21 may contribute to the progression of sporadic RCC.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Promoter hypermethylation and loss of heterozygosity of FHIT genes in squamous cell carcinoma of uterine cervix
- Expression of p16, Rb and FHIT Proteins in Urothelial Carcinoma of the Urinary Bladder
- Loss of Heterozygosity on Chromosome 3p, 9p, 17p in Oral & Oropharyngeal Squamous Cell Carcinoma
- Genetic Alterations of Tumor Suppressor Genes in Laryngeal Squamous Cell Carcinoma
- Genetic alteration of tumor suppressor gene and microsatellite in nonsmall cell lung cancer
