- Loss of Heterozygosity of p73, APC, and p53 in Hepatoblastoma
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Kim HS, Jung YM, Kim MR, Lee JY, Lee MS, Jang JJ
- KMID: 1855229
- Korean J Hepatol.
- 1999 Mar;5(1):43-49.
BACKGROUND/AIMS: The status of tumor suppression gene can be assessed indirectly by analyzing the loss of heterozygosity. Hepatoblastoma is a malignant liver tumor in childhood. To find the molecular carcinogenetic mechanism of... -
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- Loss of heterozygosity at the MCC and APC genetic loci in precancerous gastric lesion and gastric cancer
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Rhyu MG, Park WS, Jung YJ, Kim GR, Kim CS
- KMID: 1694260
- J Korean Cancer Assoc.
- 1992 Oct;24(5):695-701.
No abstract available. -
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- Molecular Genetic Study on Human Meningiomas:Loss of Heterozygosity on Chromosome 22
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Kim JH, Lee SH, Park SY, Lee JH
- KMID: 2138513
- J Korean Neurosurg Soc.
- 1991 Apr;20(4):193-198.
With the methods of restriction fragment length polymorphisms(RFLPs) and Southern blot, we performed a molecular genetic study in 20 cases of intracranial meningiomas. There were four cases of invasive meningiomas,... -
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- Loss of heterozygosity affecting MCC and APC loci in Korean colorectal adenocarcinomas
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Park WS, Yoo NJ, Choi SW, Lee KY, Lee SY, Lee JY, Kim SH, Kim JS
- KMID: 1694361
- J Korean Cancer Assoc.
- 1993 Oct;25(5):630-635.
No abstract available. -
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- Loss of Heterozygosity and Microsatellite Instability at Multiple Tumor Suppressor Genes in Gastric Carcinomas
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Cho YG, Kim CJ, Park CH, Kim YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS
- KMID: 2372736
- J Korean Gastric Cancer Assoc.
- 2003 Dec;3(4):214-220.
PURPOSE: The aim of this study was to investigate the frequency of loss of heterozygosity and the microsatellite instability at multiple tumor suppressor gene loci in gastric adenocarcinomas. MATENRIALS AND METHODS:... -
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- Adequate Microsatellite Markers for 1p/19q Loss of Heterozygosity of Oligodendroglial Tumors in Korean Patients
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Kim SH, Kim H, Kim TS
- KMID: 2275438
- Korean J Pathol.
- 2005 Feb;39(1):23-33.
BACKGROUND: It is well known that oligodendrogliomas can be divided into two groups according to the 1p/19q or 1p loss of heterozygosity (LOH) status because oligodendrogliomas with the 1p/19q LOH... -
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- Loss of Heterozygosity of Chromosome 17p in Brain Tumors
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Baek SH, Kim ES, Kim DG, Jung HW, Kim HJ, Cho BK, Han DH, Lee SH, Kim JH
- KMID: 2019506
- J Korean Neurosurg Soc.
- 1992 Jan;21(1):23-29.
With the methods of restriction fragment length polymorphisms(RFLPs) and southern blot analysis, gene deletion of chromosome 17p in 16 cases of brain tumors, was investigated. There were 4 cases of... -
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- Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
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Ha TW, Han KH, Son DG, Kim SP, Kim DK
- KMID: 1095217
- J Korean Med Sci.
- 2005 Apr;20(2):340-343.
- doi: 10.3346/jkms.2005.20.2.340
Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and... -
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- Loss of Heterozygosity at 1p, 7q, 17p, and 22q in Meningiomas
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Chang IB, Cho BM, Moon SM, Park SH, Oh SM, Cho SJ
- KMID: 2190319
- J Korean Neurosurg Soc.
- 2010 Jul;48(1):14-19.
- doi: 10.3340/jkns.2010.48.1.14
OBJECTIVE: Allelic losses or loss of heterozygosity (LOH) at many chromosomal loci have been found in the cells of meningiomas. The objective of this study was to evaluate LOH at... -
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- Relation between Loss of Heterozygosity of APC gene and: Catenin Expression in Gastric Cancer
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Kim JK, Moon SB, Choo KY, Park SH, Choi MG, Han JY, Chung KW, Sun HS
- KMID: 1857606
- Korean J Gastroenterol.
- 2000 Jun;35(6):724-731.
BACKGROUND/AIMS: Wide-type Adenomatous polyposis coli (APC) gene binds to beta-catenin and APC mutants lead to cytosolic accumulation of beta-catenin which serves as a component of carcinogenesis. We investigated the relationship... -
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- Inactivation Pattern of p16 Gene in Non-Hodgkin's Lymphomas
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Cho HD, Kim IS
- KMID: 1725935
- Korean J Pathol.
- 2002 Dec;36(6):365-373.
BACKGROUND: Loss of heterozygosity (LOH) and mutation of the p16 tumor suppressor gene have been detected in non-Hodgkin's lymphomas (NHLs). Recently, hypermethylation of the p16 gene has been reported. The... -
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- Loss of Heterozygosity and PCR Artifacts in a Microsatellite Analysis of Psoriasis and Colorectal Cancer
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Hyun JS, Jo BK, Park CJ, Yi JY, Lee JY, Rhyu MG
- KMID: 1127256
- J Korean Med Sci.
- 2002 Oct;17(5):641-647.
- doi: 10.3346/jkms.2002.17.5.641
Although a loss of heterozygosity (LOH) is commonly observed using microsatellite markers in a cell-proliferating malignant disorder, controversial findings of psoriasis, a keratinocyte-outgrowth disease, remain to be explained. It... -
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- Analysis of Microsatellite Instability and Loss of Heterozygosity in Sporadic Keratoacanthoma
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Ha TW, Han KH, Kim DK
- KMID: 2030772
- Korean J Anat.
- 2005 Feb;38(1):55-61.
Tumors from patients with hereditary non-polyposis colorectal cancer (HNPCC)and from a subset of patients with the related Muir-Torre syndrome exhibit a type of a genetic instability, known as microsatellite instability... -
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- Analysis of Loss of Heterozygosity on the Chromosome 3, 4, 5 and 11 in Uterine Cervical Carcinomas
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Nam JH, Jung JJ, Choi C
- KMID: 2172444
- Chonnam Med J.
- 2000 Dec;36(4):349-356.
Infection of cervical epithelial cells with specific human papilloma virus subtypes appears to be necessary etiological factors for most cervical carcinomas, but yet additional genetic changes such as activation of... -
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- Loss of Heterozygosity on Chromosome 9p21, 17p13 and 3p in Human Astrocytic Tumor
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Lee YS, Kang CS, Dong SM, Lee JY, Shim SI, Kim BK
- KMID: 1725821
- Korean J Pathol.
- 2001 Aug;35(4):330-337.
BACKGROUND: The purpose of this study was to determine the genetic abnormalities of chromosomes 9p21, 17p13.1, 3p25 and 3p14.2 in the development and progression of astrocytic tumors. METHODS: We performed... -
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- PCR-based Study on Loss of Heterozygosity at the Short Arm of Chromosome 3 in Renal Cell Carcinoma
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Yoon JH, Park YH, Kim IH
- KMID: 1991363
- Korean J Urol.
- 1996 Jul;37(7):730-738.
Loss of heterozygosity (LOH) at polymorphic loci on the short arm of chromosome 3 which has multiple recurrence genes was investigated in histopathologically proven 35 sporadic renal cell carcinoma (RCC)... -
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- Recessive allelic loss in colorectal cancer tissue
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Cho WI, Yoo SJ, Chang SK, Kim SN, Song YT, Lee JH, Joo SY
- KMID: 1694399
- J Korean Cancer Assoc.
- 1993 Dec;25(6):848-854.
No abstract available. -
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- Loss of Heterozygosity using Microsatellite Marker in plasma of patients with ovarian cancer
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Kim YM, Kim YT, Lee KW
- KMID: 2076675
- Korean J Obstet Gynecol.
- 2002 Sep;45(9):1505-1510.
OBJECTIVE: Recent studies demonstrated that soluble tumor DNA is found in the plasma of cancer patients, and some microsatellite alteration have been identified in ovarian carcinoma. The aim of study... -
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- Promoter hypermethylation and loss of heterozygosity of FHIT genes in squamous cell carcinoma of uterine cervix
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Ko OJ, Choi CH, Kim TJ, Kim WY, Lee KM, Choi JJ, Lee JW, Kim BG, Lee JH, Bae DS
- KMID: 2244565
- Korean J Gynecol Oncol.
- 2007 Jun;18(2):139-145.
OBJECTIVE: This study was to investigate the status of hypermethylation and loss of heterozygosity (LOH) in chromosome 3p tumor-suppressor gene for cervical carcinoma. METHODS: We examined the promoter methylation status... -
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- Genomic Instability in Colorectal Cancer; from Bench to Bed
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Lee KY
- KMID: 2334430
- J Korean Soc Coloproctol.
- 2009 Apr;25(2):129-138.
Colorectal cancer is a disease developed by the accumulation of genomic alteration. Two genomic instability pathways, chromosomal instability pathway and microsatellite instability pathway, are known as the main pathways of... -
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