J Korean Med Sci.  2010 Aug;25(8):1187-1190. 10.3346/jkms.2010.25.8.1187.

Effects of Body Composition, Leptin, and Adiponectin on Bone Mineral Density in Prepubertal Girls

• Rhie YJ
• Lee KH
• Chung SC
• Kim HS
• Kim DH

• KMID: 1714041
• DOI: http://doi.org/10.3346/jkms.2010.25.8.1187

Abstract

Body weight is positively associated with bone mineral density but the relationship between obesity and bone mineral density is unclear. Leptin and adiponectin are potential independent contributors to bone mineral density. We assessed the correlations of body composition, leptin and adiponectin with bone mineral density, and whether leptin, adiponectin and body composition determine bone mineral density independently in prepubertal girls. Forty-eight prepubertal girls were classified into obese and control groups by body mass index. Serum leptin and adiponectin levels were determined by enzyme immunoassay. Bone mineral density was measured using dual energy radiography absorptiometry and body composition was measured using bioelectrical impedance analysis. Lean and fat mass, and leptin were positively correlated with bone mineral density. Lean mass was a positive independent predictor of femoral and L-spine bone mineral density. Serum leptin was a postivie independent predictor of femoral bone mineral density. Fat mass was a negative independent predictor of femoral bone mineral density. In prepubertal girls, lean mass has a favorable effect on bone mineral density. Fat mass seems not to protect the bone structure against osteoporosis, despite increased mechanical loading. Serum leptin may play a biological role in regulating bone metabolism.

Keyword

Bone Density; Body Composition; Leptin; Adiponectin; Obesity

MeSH Terms

Absorptiometry, Photon
Adiponectin/*blood
*Body Composition
*Bone Density
Child
Electric Impedance
Female
Humans
Leptin/*blood
Obesity/etiology

Reference

1. Gascon F, Valle M, Martos R, Zafra M, Morales R, Castano MA. Childhood obesity and hormonal abnormalities associated with cancer risk. Eur J Cancer Prev. 2004. 13:193–197.

2. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004. 350:2362–2374.

3. Thomas T, Burguera B. Is leptin the link between fat and bone mass? J Bone Miner Res. 2002. 17:1563–1569.

4. Bouillon R, Prodonova A. Growth and hormone deficiency and peak bone mass. J Pediatr Endocrinol Metab. 2000. 13:Suppl 6. 1327–1336.

5. Albrand G, Munoz F, Sornay-Rendu E, DuBoeuf F, Delmas PD. Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. Bone. 2003. 32:78–85.

6. Reid IR. Relationships among body mass, its components, and bone. Bone. 2002. 31:547–555.

7. Espallargues M, Sampietro-Colom L, Estrada MD, Sola M, del Rio L, Setoain J, Granados A. Identifying bone-mass-related risk factors for fracture to guide bone densitometry measurements: a systematic review of the literature. Osteoporos Int. 2001. 12:811–822.

8. Van Langendonck L, Claessens AL, Lefevre J, Thomis M, Philippaerts R, Delvaux K, Lysens R, Vanden Eynde B, Beunen G. Association between bone mineral density (DXA), body structure, and body composition in middle-aged men. Am J Hum Biol. 2002. 14:735–742.

9. Khosla S, Atkinson EJ, Riggs BL, Melton LJ 3rd. Relationship between body composition and bone mass in women. J Bone Miner Res. 1996. 11:857–863.

10. Wang MC, Bachrach LK, Van Loan M, Hudes M, Flegal KM, Crawford PB. The relative contributions of lean tissue mass and fat mass to bone density in young women. Bone. 2005. 37:474–481.

11. Lazcano-Ponce E, Tamayo J, Cruz-Valdez A, Diaz R, Hernandez B, Del Cueto R, Hernandez-Avila M. Peak bone mineral area density and determinants among females aged 9 to 24 years in Mexico. Osteoporos Int. 2003. 14:539–547.

12. Young D, Hopper JL, Macinnis RJ, Nowson CA, Hoang NH, Wark JD. Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8 to 26-year-old female twins. Osteoporos Int. 2001. 12:506–515.

13. Janicka A, Wren TA, Sanchez MM, Dorey F, Kim PS, Mittelman SD, Gilsanz V. Fat mass is not beneficial to bone in adolescents and young adults. J Clin Endocrinol Metab. 2007. 92:143–147.

14. Klein KO, Larmore KA, de Lancey E, Brown JM, Considine RV, Hassink SG. Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J Clin Endocrinol Metab. 1998. 83:3469–3475.

15. Yamauchi M, Sugimoto T, Yamaguchi T, Nakaoka D, Kanzawa M, Yano S, Ozuru R, Sugishita T, Chihara K. Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women. Clin Endocrinol (Oxf). 2001. 55:341–347.

16. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001. 7:941–946.

17. Luo XH, Guo LJ, Xie H, Yuan LQ, Wu XP, Zhou HD, Liao EY. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res. 2006. 21:1648–1656.

18. Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J, Yoshikawa H, Shimomura I. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun. 2005. 331:520–526.

19. Sugiyama T, Yamaguchi A, Kawai S. Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the "mechanostat" theory. J Bone Miner Metab. 2002. 20:196–200.

20. Glauber HS, Vollmer WM, Nevitt MC, Ensrud KE, Orwoll ES. Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. J Clin Endocrinol Metab. 1995. 80:1118–1123.

21. Petit MA, Beck TJ, Shults J, Zemel BS, Foster BJ, Leonard MB. Proximal femur bone geometry is appropriately adapted to lean mass in overweight children and adolescents. Bone. 2005. 36:568–576.

22. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G. Leptin regulates bone formation via the sympathetic nervous system. Cell. 2002. 111:305–317.

23. Martini G, Valenti R, Giovani S, Franci B, Campagna S, Nuti R. Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women. Bone. 2001. 28:113–117.

24. Papadopoulou F, Krassas GE, Kalothetou C, Koliakos G, Constantinidis TC. Serum leptin values in relation to bone density and growth hormone-insulin like growth factors axis in healthy men. Arch Androl. 2004. 50:97–103.

25. Lorentzon M, Landin K, Mellstrom D, Ohlsson C. Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men. J Bone Miner Res. 2006. 21:1871–1878.

26. Luo XH, Guo LJ, Yuan LQ, Xie H, Zhou HD, Wu XP, Liao EY. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res. 2005. 309:99–109.

27. Richards JB, Valdes AM, Burling K, Perks UC, Spector TD. Serum adiponectin and bone mineral density in women. J Clin Endocrinol Metab. 2007. 92:1517–1523.

28. Huang KC, Cheng WC, Yen RF, Tsai KS, Tai TY, Yang WS. Lack of independent relationship between plasma adiponectin, leptin levels and bone density in nondiabetic female adolescents. Clin Endocrinol (Oxf). 2004. 61:204–208.

29. Kontogianni MD, Dafni UG, Routsias JG, Skopouli FN. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res. 2004. 19:546–551.

30. Schwartz AV. Diabetes Mellitus: Does it Affect Bone? Calcif Tissue Int. 2003. 73:515–519.