J Korean Med Sci.  2010 Aug;25(8):1187-1190. 10.3346/jkms.2010.25.8.1187.

Effects of Body Composition, Leptin, and Adiponectin on Bone Mineral Density in Prepubertal Girls

• Rhie YJ
• Lee KH
• Chung SC
• Kim HS
• Kim DH

• KMID: 1714041
• DOI: http://doi.org/10.3346/jkms.2010.25.8.1187

Abstract

Body weight is positively associated with bone mineral density but the relationship between obesity and bone mineral density is unclear. Leptin and adiponectin are potential independent contributors to bone mineral density. We assessed the correlations of body composition, leptin and adiponectin with bone mineral density, and whether leptin, adiponectin and body composition determine bone mineral density independently in prepubertal girls. Forty-eight prepubertal girls were classified into obese and control groups by body mass index. Serum leptin and adiponectin levels were determined by enzyme immunoassay. Bone mineral density was measured using dual energy radiography absorptiometry and body composition was measured using bioelectrical impedance analysis. Lean and fat mass, and leptin were positively correlated with bone mineral density. Lean mass was a positive independent predictor of femoral and L-spine bone mineral density. Serum leptin was a postivie independent predictor of femoral bone mineral density. Fat mass was a negative independent predictor of femoral bone mineral density. In prepubertal girls, lean mass has a favorable effect on bone mineral density. Fat mass seems not to protect the bone structure against osteoporosis, despite increased mechanical loading. Serum leptin may play a biological role in regulating bone metabolism.

Keyword

Bone Density; Body Composition; Leptin; Adiponectin; Obesity

MeSH Terms

Absorptiometry, Photon
Adiponectin/*blood
*Body Composition
*Bone Density
Child
Electric Impedance
Female
Humans
Leptin/*blood
Obesity/etiology