Korean J Dermatol.  1994 Jun;32(3):399-408.

Detection of Human Papillomavirus DNA in Bowen' s Disease and Squamous Cell Carcinoma of the Skin

• Cho KH
• Kim YG
• Park KC
• Song YS
• Choi YM
• Kim CW

Abstract

BACKGROUND: It has been suggested that human papillomavirua(HPV) infection has been implicated in the pathogenesis of between disease and squamous cell cacoma of the skin, particularly of snogenital area. There is little knowledge about etiologic characteriscs of the development of Bowens disease and squamous cell earcinoma of the skin in Korean patients.
OBJECTIVE
This study is intended to evaluate Bowens disease and squamous cell carcinoma of the skin in Korean patients for the presence of HPV.
METHODS
Fifteen cases of Bowens disease and fifteen cases of cutaneous squamous cell carcinoma were investigated. All cases developed on a nongenital site. In situ lybridization and polymerase chain reaction(PCR) were used for detection of HPV DNA in paraffinem bedded tissue sections. The clinical records and slides of these cases were reviewed for the analysis of clinicopathologic characteristiqs of HPV DNA positive eases.
RESULTS
By in situ hybidization HPV 16 was detected in thrw cases(20%) with Bowens disease. By PCR HPV 16 was detected in six cases(40% ) of Bowens digreae and five cases(33.3) of squamous cell carcinoma of the skin. No specific clinicopathologic fetetues were found to be indicative of the presence or absence of HPV.
CONCLUSION
These data suggest a role for HPV in the evolution of Bowens disease and squamous cell carcinoms of the skin in Korean patients.

Keyword

Human Papillomavirus; Bowens Disease; Squamous Cell Carinoma

MeSH Terms

Bowen's Disease
Carcinoma, Squamous Cell*
DNA*
Human papillomavirus 16
Humans*
Polymerase Chain Reaction
Skin*
DNA