Yonsei Med J.  2005 Feb;46(1):155-158. 10.3349/ymj.2005.46.1.155.

Warty Squamous Cell Carcinoma of the Vulva in Older Women: Association with Human Papillomavirus

• Jang YH
• Kim YC
• Lee ES

• KMID: 2158126
• DOI: http://doi.org/10.3349/ymj.2005.46.1.155

Abstract

Warty squamous cell carcinoma (WSCC), a rare variant of squamous cell carcinoma occurring in younger women, is primarily associated with human papillomavirus (HPV) infection. Although WSCC appears to exhibit less aggressive behavior than typical well-differentiated squamous cell carcinoma, it bears the risk of regional metastasis. Accordingly, WSCC should be differentiated from other verruciform neoplasms. We describe a rare case of WSCC with a short disease duration occurring in a woman of old age. We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray. These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

Keyword

Wart; squamous cell carcinoma; human papillomavirus; DNA microarray

MeSH Terms

Aged
Carcinoma, Squamous Cell/pathology/*virology
Female
Humans
Papillomavirus Infections/*complications/pathology
*Papillomavirus, Human
Skin Neoplasms/pathology/*virology
Vulvar Neoplasms/pathology/*virology

Figure

• 

  Fig. 1 A verrucous and pedunculated mass on the left vulva.

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  Fig. 2 (a) A papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis (haematoxylin and eosin; original magnification: × 40). Round and tapering dermal papillae with a fibrovascular core (×100). (b) Invasion of the dermis by irregularly shaped, jagged nests of epithelium, the cells which are predominantly mature squamous cells showing atypicality (haematoxylin and eosin; original magnification: ×50). The invading tumor masses are composed of atypical squamous cells (× 200). (c) Cells within the tumor nest demonstrate koilocytosis with large, wrinkled, hyperchromatic nuclei, and horn pearl is present (haematoxylin and eosin; original magnification: ×400).

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  Fig. 3 HPV DNA chip microarray format (Left). DNA chip microarray for HPV types show the presence of other type HPV DNA in this case, but not the high and low risk HPV types. (Left: DNA chip microarray format; right: results in this case, other HPV DNA types positive.)

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