Korean J Urogenit Tract Infect Inflamm.  2013 Apr;8(1):52-54. 10.14777/kjutii.2013.8.1.52.

Synchronous Verrucous Carcinoma and Squamous Cell Carcinoma of Penis by Different Human Papillomavirus Infections

Affiliations
  • 1Department of Urology, Dankook University College of Medicine, Cheonan, Korea. multiorigins@yahoo.com

Abstract

Synchronous verrucous carcinoma and squamous cell carcinoma of the penis is a rare condition. We report on a case of penile carcinoma with a well demarcated and ulcerated endophytic squamous carcinoma lesion by human papillomavirus 16 and 61 types, and a whitish exophytic verrucous carcinoma lesion by an unknown lower risk human papillomavirus type.

Keyword

Verrucous carcinoma; Carcinoma, Squamous cell; Human papilloma virus

MeSH Terms

Carcinoma, Squamous Cell*
Carcinoma, Verrucous*
Human papillomavirus 16
Humans*
Male
Papillomavirus Infections*
Penis*
Ulcer

Figure

  • Fig. 1. Gross appearance of the penile lesions. (A) Whitish condyloma like lesion on frenulum, dorsal area of penis and around the urethral meatus. (B) Necrotic and denuded area of penis.

  • Fig. 2. The results of microarray of whitish condyloma like lesion (A), necrotic lesion (B), and reference (C). Box on (A) revealed the presence of other human papilloma virus. The dotted boxes on (B) revealed the presence of human papilloma virus types 16 and 61.


Reference

1. Calmon MF, Tasso Mota M, Vassallo J, Rahal P. Penile carcinoma: risk factors and molecular alterations. Scientific World Journal. 2011; 11:269–82.
Article
2. Chaux A, Cubilla AL. The role of human papillomavirus infection in the pathogenesis of penile squamous cell carcinomas. Semin Diagn Pathol. 2012; 29:67–71.
Article
3. Lee GH. Use of consensus primer set, GP5+ and GP6+, to detect human papillomavirus within genital lesions. Korean J Urol. 2003; 44:606–10.
4. http://www.ncbi.nlm.nih.gov/Taxonomy/taxonomyhome.html
5. Ferreux E, Lont AP, Horenblas S, Gallee MP, Raaphorst FM, von Knebel Doeberitz M, et al. Evidence for at least three alternative mechanisms targeting the p16INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus. J Pathol. 2003; 201:109–18.
Article
6. Beer-Romero P, Glass S, Rolfe M. Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. Oncogene. 1997; 14:595–602.
Article
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