J Korean Pain Soc.  1989 Nov;2(2):194-197.

Therapeutic Effect of Transdermal Scopolamine Patch on Nausea and Vomiting associated with Epidural Morphine

• Woo NS

Abstract

Epidural morphine provides excellent analgesia for the management of postoperative pain, but nausea and vomiting are a commonly reported side effect. Scopolamine, a belladona alkaloid, is an effective antiemetic when nausea is induced by morphine. Transdermal scopolamine patches have the advantage of delivering a constant low dosage of the drug over a prolonged period. To evaluate the efficacy of prophylacitic transdermal scopolamine in reducing nausea or vomiting associated with postoperative epidural morphine analgesia, I studied 60 healthy adult patients. The patients were divided into 3 groups, each group consisting of 20 patients. Group 1; no scopolamine for control Group 2; transdermal scopolamine placebo patch Group 3; transdermal scopolamine patch All patients were anesthetized by epidural injection of 2% lidocaine 15 ml and 0.5% bupivacaine 10 ml with morphine 4 mg. A Comparison with the control group, the placebo group, and Group 3, indicated, that the transdermal scopolamine reduced the incidence of nausea or vomiting associated with postoperative epidural morphine analgesia (group 1; 35%, group 2; 25%, group 3; 10%). However there were no statisfically significant differences between groups at a level of p>0.05.

Keyword

ANESTHETICS; EPIDURAL-lidocaine; Morphine; Bupovacine; ANTIEMETICS-transdermal scopolamine patch; SIDE EFFECTS-nausea; Vomiting

MeSH Terms

Adult
Analgesia
Anesthetics
Bupivacaine
Humans
Incidence
Injections, Epidural
Lidocaine
Morphine*
Nausea*
Pain, Postoperative
Scopolamine Hydrobromide*
Vomiting*
Anesthetics
Bupivacaine
Lidocaine
Morphine
Scopolamine Hydrobromide