Korean J Anesthesiol.  1993 Jun;26(3):434-438. 10.4097/kjae.1993.26.3.434.

Effect of Transdermal scopolamine Patch on Nausea or Vomiting Associated with General Anesthesia

• Jang JS
• Oh JH
• Jang JG

• KMID: 2145913
• DOI: http://doi.org/10.4097/kjae.1993.26.3.434

Abstract

To evaluate the efficacy of transdermal scopolamine patch in reducing nausea and vomiting associated with general anesthesia, we studied 60 healthy women undergoing major gynecologic surgery. The patients were divided into 2 groups. Each group was composed of 30 patients. Group I; not applied a transdermal scopolamine patch. Group II: applied one transdermal scopolamine patch on the skin behind her ear at the night before surgery. Anesthesia was induced by thiopental sodium(5 mg/kg) and succinylcholine(1.5 mg/kg) and maintained with fentanyl(3-6 ug/kg), enflurane(0.5-1.5 vol%) and nitrous oxide(50 vo1%) in oxygen. A comparison with Group I and Group II indicated that the transdermal scopolamine patch reduced the incidence of postoperative nausea or vomiting associated with general anesthesia significantly(Group I; 36.67%, Group II; 13.33%, p<0.05).

Keyword

Postanesthesia; Nausea; Vomiting; Antiemetics; Transdermal scopolamine patch

MeSH Terms

Anesthesia
Anesthesia, General*
Antiemetics
Ear
Female
Gynecologic Surgical Procedures
Humans
Incidence
Nausea*
Oxygen
Postoperative Nausea and Vomiting
Scopolamine Hydrobromide*
Skin
Thiopental
Vomiting*
Antiemetics
Oxygen
Scopolamine Hydrobromide
Thiopental