J Korean Pain Soc.  1996 Jun;9(1):178-182.

Prophylactic Effects of Transdermal Scopolamine Patches on Nausea in Postoperative Patients Receiving Epidural Morphine

• Kim JW
• Lee C
• Suh BT

Abstract

BACKGROUND: To evaluate the effect of prophylactic transdermal scopolamine in reducing nausea associated with postoperative epidural morphine.
METHODS
30 healthy patients scheduled for c-sarean section were given local anesthetics epidurally for surgical anesthesia. After delivery of the baby, transdermal scopolamine patch (Kimite Myung Moon Pharm. Co., Seoul, Korea) was applied to the study group (n=15) and placebo patch to the control group (n=15). Postoperative analgesia was provided soley with epidural morphine. Nausea was treated with metoclopramide.
RESULTS
During 24 hours postoperatively, the mean nausea score was significantly lower in the study group than in the control group. But the nausea incidence was not significantly different between the two groups. The mean number of times antiemetic drugs which were administered to patients were lower in the study group than in the control group (1.5 +/- 0.5 vs 3.3 +/- l.3, p < 0.05).
CONCLUSIONS
Transdermal scopolamine patch provides antiemetic effect simply, continuously and safely, preventing nausea which could occur during administration of epidural morphine after cesarean section.

Keyword

Epidural morphine; Nausea & vomiting; Transdermal scopolamine

MeSH Terms

Analgesia
Anesthesia
Anesthetics, Local
Antiemetics
Cesarean Section
Female
Humans
Incidence
Metoclopramide
Morphine*
Nausea*
Pregnancy
Scopolamine Hydrobromide*
Seoul
Anesthetics, Local
Antiemetics
Metoclopramide
Morphine
Scopolamine Hydrobromide