Ewha Med J.  1992 Jun;15(2):139-144. 10.12771/emj.1992.15.2.139.

The Antiemetic Effect of Transdermal Scopolamine Following Outpatient Laparoscopy

• Kim JH
• Lee CH

• KMID: 1965116
• DOI: http://doi.org/10.12771/emj.1992.15.2.139

Abstract

The aim of this study was to evaluate the effects of a transdermal scopolamine patch on the incidence and severity of postoperative nausea and vomiting in patients undergoing outpatient laparoscopy. Transdermal scopolamine patch was placed behind ear the night before surgery in study group. Anesthesia was induced with thiopental(4~5mg/ku iv) and succinylcholine(1.5mg/kg) and maintained with meperidine. valium and N2O(50%) in O2. The results were as follows : 1) Scopolamine-treated patients had significantly less nausea and vomiting compared with control group. Nausea and/or vomiting was present in 46.4% of the control group but only 18.5% of those getting the scopolamine-treated group. 2) Side effects were more frequent among scopollamine-treated patients than control patients (77.8% vs 32.1%) but were not troublesome The common reported side effects were a dry mouth and dizziness. In conclusion transdermal scopolamine appears to be an effective antiemetic agent in patients undergoing outpatient laparoscopy.

MeSH Terms

Anesthesia
Antiemetics*
Diazepam
Dizziness
Ear
Humans
Incidence
Laparoscopy*
Meperidine
Mouth
Nausea
Outpatients*
Postoperative Nausea and Vomiting
Scopolamine Hydrobromide*
Vomiting
Antiemetics
Diazepam
Meperidine
Scopolamine Hydrobromide