Korean J Physiol Pharmacol.  2004 Dec;8(6):295-300.

Effect of Fluoxetine on the Induction of Long-term Potentiation in Rat Frontal Cortex

• Kim HS
• Kim HS
• Hahn SJ
• Kim MJ
• Yoon SH
• Jo YH
• Kim MS
• Rhie DJ

Abstract

Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as a selective serotonin reuptake inhibitor, is used in the management of a wide variety of psychological diseases. To study the effect of fluoxetine on the induction of LTP, we recorded the field potential in layer II/III of the frontal cortex from 3-wk-old. LTP was induced in horizontal input by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 (50microM), an NMDA receptor antagonist. Whereas bath application of 5-HT (10microM) inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine (PCA, 10microM), for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and 10microM) suppressed the induction of LTP in concentration-dependent manner, however, fluoxetine did not inhibit the induction of LTP in 5-HT-depleted slices. These results indicate that fluoxetine may inhibit the induction of LTP by modulating serotonergic mechanism in the rat frontal cortex.

Keyword

Serotonin; Fluoxetine; Long-term potentiation; Frontal cortex

MeSH Terms

Animals
Baths
Fluoxetine*
Hippocampus
Long-Term Potentiation*
N-Methylaspartate
p-Chloroamphetamine
Prefrontal Cortex
Rats*
Serotonin
Visual Cortex
Fluoxetine
N-Methylaspartate
Serotonin
p-Chloroamphetamine