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Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells

Hwang S, Kim JK

We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours...
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Antidepressant Prescription Patterns in Bipolar Disorder: a Nationwide, Register-based Study in Korea

Yoon W, Shon SH, Hong Y, Joo YH, Lee JS

BACKGROUND: The role of antidepressants (ADs) in bipolar disorder is long-standing controversial issue in psychiatry. Many clinicians have used ADs as a treatment for bipolar depression, and the selection of...
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Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case

Guler G, Kutuk MO, Kara H

Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known...
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The Effect of Antidepressants on Mesenchymal Stem Cell Differentiation

Kruk JS, Bermeo S, Skarratt K, Fuller SJ, Duque G

BACKGROUND: Use of antidepressant medications has been linked to detrimental impacts on bone mineral density and osteoporosis; however, the cellular basis behind these observations remains poorly understood. The effect does...
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Urticaria and Angioedema Associated with Fluoxetine

Tuman TC, Tuman B, Polat M, Çakır U

No abstract available.
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Prescription Pattern of Antidepressants for Children and Adolescents in Korea Based on Nationwide Data

Chon MW, Lee J, Chung S, Kim Y, Kim HW

Antidepressant prescription for youths has recently been on the increase. There is a growing concern over the increasing off-label usage of antidepressants. Current data on off-label antidepressant usage vary across...
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Serotonin Syndrome following Duloxetine Administration in a Fibromyalgia Patient: Case Report and Literature Review

Choi JS, Lee JH, Park SK, Shim BJ, Choi WK, Kim SH, Hwang SC

Serotonin syndrome, an adverse drug reaction, is a consequence of excess serotonergic agonism of central nervous system receptors and peripheral serotonergic receptors. Serotonin syndrome has been associated with large numbers...
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Effects of analgesics and antidepressants on TREK-2 and TRESK currents

Park H, Kim EJ, Han J, Han J, Kang D

TWIK-related K+ channel-2 (TREK-2) and TWIK-related spinal cord K+ (TRESK) channel are members of two-pore domain K+ channel family. They are well expressed and help to set the resting membrane...
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Times to Discontinue Antidepressants Over 6 Months in Patients with Major Depressive Disorder

Jung WY, Jang SH, Kim SG, Jae YM, Kong BG, Kim HC, Choe BM, Kim JG, Kim CR

OBJECTIVE: The aim of the present study was to investigate differences in discontinuation time among antidepressants and total antidepressant discontinuation rate of patients with depression over a 6 month period...
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Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine

Chatterjee SS, Mitra S, Mallik N

While fluoxetine (FXT) is a frequently prescribed selective serotonin reuptake inhibitor (SSRI), with few major side-effects; altered serotonergic transmissions in hypothalamic pathways might lead to a distressing, and often embarrassing,...
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Association between ABCB1 Polymorphisms and Antidepressant Treatment Response in Taiwanese Major Depressive Patients

Chang HH, Chou CH, Yang YK, Lee IH, Chen PS

OBJECTIVE: The multidrug resistance 1 (ABCB1, MDR1) gene, encoding P-glycoprotein, is extensively distributed and expressed in various tissues, such as a blood-brain barrier transporter. P-glycoprotein plays an important role in...
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Chronic Antidepressant Treatment in Normal Mice Induces Anxiety and Impairs Stress-coping Ability

Baek IS, Park JY, Han PL

Antidepressants are clinically used for patients with major depression. Antidepressant treatments in certain groups of patients are effective for relieving depression as well as anxiety disorder. However, it is not...
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Psychiatric Symptoms in Temporal Lobe Epilepsy with Left Mesial Hippocampal Sclerosis

Jang H, Kim SH, Park SH, Choo IH, Kim SG

A 16-year-old woman was referred to us for depression and persistent suicidal and homicidal ideation. From 2010, the patient visited a neurologist due to recurrent grand mal epilepsy, auditory and...
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Effects of Clozapine, Haloperidol, and Fluoxetine on the Reversal of Cocaine-Induced Locomotor Sensitization

Cha SK, Kang UG

OBJECTIVE: Repeated treatment with psychostimulants induces sensitization of the dopaminergic system in the brain. Dopaminergic sensitization has been proposed as a mechanism of psychosis. Although antipsychotics block the expression of...
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Changes of Body Weight and Metabolic Syndrome in Psychiatric Inpatients

Jang WY, Lee KH, Bae NR, Lee SM, Kim TW, Sakong JK, Kwak KP

OBJECTIVE: This study explored the development of metabolic syndrome, changes in body weight and metabolic syndrome parameters (waist circumference, serum glucose and lipids, blood pressure), and effects of psychotropic agents...
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Korean Pharmacological Treatment Guideline for Child-Adolescent Depression: The Efficacy and Choice of Antidepressant

Song HR, Lee YH, Yang S, Lee JY, Jang JW, Jeong S, Jeong H, Jo SJ, Yim HW, Lee SY, Jun TY

OBJECTIVE: The purpose of this guideline was to suggest recommendations for appropriate use of antidepressants in the child-adolescent depression. The differences of efficacy among antidepressants were evaluated. METHODS: Four kinds of...
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Alterations of Amino Acid Level in Depressed Rat Brain

Yang P, Li X, Ni J, Tian J, Jing F, Qu C, Lin L, Zhang H

Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of depression. Several studies have demonstrated the potential of amino acids as a source of neuro-specific biomarkers could be...
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Antidepressant-induced Burning Mouth Syndrome: A Unique Case

Raghavan S, Puttaswamiah RN, Birur PN, Ramaswamy , Sunny SP

Burning Mouth Syndrome (BMS) is defined as a chronic orofacial pain syndrome, without evidence of mucosal lesions and other clinical signs of disease or laboratory abnormalities. Patients with BMS complain...
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Development of a LC-MS/MS for Quantification of Venlafaxine in Human Plasma and Application to Bioequivalence Study in healthy Korean Subjects

Kang HK, Kang MA, Kim HJ, Park YS, Kim SH, Kang JS

  • KMID: 2317857
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):35-42.
A simple, rapid and selective liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is developed and validated for quantification of venlafaxine in human plasma with simple liquid-liquid extraction step consisted...
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A Case of Pulmonary Thromboembolism Complicating Acute Overdose of Benzodiazepines

Choi JY, Jeong J

  • KMID: 2333825
  • J Korean Soc Emerg Med.
  • 2014 Apr;25(2):199-201.
Acute pulmonary thromboembolism (PTE) is a major medical problem in many hospitalized patients with medical and surgical conditions, and venous thromboembolism is responsible for up to 15% of all in-hospital...
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