Clin Psychopharmacol Neurosci.  2015 Dec;13(3):316-318. 10.9758/cpn.2015.13.3.316.

Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine

Affiliations
  • 1Department of Psychiatry, Medical College, Kolkata, India.
  • 2Department of Psychiatry, Sarojini Naidu Medical College, Agra, India. sayantanava@gmail.com

Abstract

While fluoxetine (FXT) is a frequently prescribed selective serotonin reuptake inhibitor (SSRI), with few major side-effects; altered serotonergic transmissions in hypothalamic pathways might lead to a distressing, and often embarrassing, manifestation of galactorrhea by altering prolactin release in those on FXT. We report here a case of FXT-induced hyperprolactinemic galactorrhea developing late into treatment on a stable regimen, who responded well to subsequent replacement with sertraline. Based on present finding, we suggest that while SSRIs may share similar mechanisms of action, there exist individual differences in their effects on prolactin secretion pathways.

Keyword

Fluoxetine; Galactorrhea; Hyperprolactinemia; Selective serotonin reuptake inhibitors

MeSH Terms

Female
Fluoxetine*
Galactorrhea*
Hyperprolactinemia
Individuality
Obsessive-Compulsive Disorder*
Pregnancy
Prolactin
Secretory Pathway
Serotonin
Serotonin Uptake Inhibitors
Sertraline
Fluoxetine
Prolactin
Serotonin
Serotonin Uptake Inhibitors
Sertraline
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