Korean J Physiol Pharmacol.  2005 Jun;9(3):149-153.

Preventive Effect of Serotonergic Drugs on LPS-Induced Acute Anorexia in Rats

• Park SY
• Kim KH
• Ahn DK
• Park TI
• Kim JY
• Kim YW
• Lee DC
• Lee SK

Abstract

The aim of the present study was to determine whether serotonergic drugs could reverse lipopolysaccharide (LPS) -induced anorexia in rats. LPS (500microgram/kg body weight) and all serotonergic drugs, except for 8-OH-DPAT (subcutaneous), were injected intraperitoneally into Sprague-Dawley rats. Without the LPS injection, 8-OH-DPAT (1A agonist), metergoline (1/2 antagonist), and mianserin (2A/2C antagonist) exerted no effects on food intake at any of the doses tested, but ketanserin (2A antagonist) caused an increase of food intake at 4 mg/kg. RS-102221 (2C antagonist) reduced food intake at 2 and 4 mg/kg. LPS reduced food intake 1 hour after injection, and food intake remained low until the end of measurement period (24 hours) (p< 0.05). Pretreatment of rats with 8-OH-DPAT partially recovered of cumulative food intake at all measured times (2, 4, 6, 8, and 24 hours after LPS injection). Pretreatment with metergoline resulted in a partial recovery of cumulative food intake at 2, 4, 6, and 8 hours, but not at 24 hours. Ketanserin caused partial recovery at 2 and 4 hours only. Mianserin and RS-102221 had no effects on LPS-reduced food intake. A variety of serotonergic drugs ameliorated anorexic symptoms, which suggesting that the serotonin system plays a role in LPS-induced anorexia.

Keyword

Lipopolysaccharide; Anorexia; Serotonin; Serotonergic drug; Rat

MeSH Terms

8-Hydroxy-2-(di-n-propylamino)tetralin
Animals
Anorexia*
Diethylpropion
Eating
Ketanserin
Metergoline
Mianserin
Rats*
Rats, Sprague-Dawley
Serotonin
Serotonin Agents*
8-Hydroxy-2-(di-n-propylamino)tetralin
Diethylpropion
Ketanserin
Metergoline
Mianserin
Serotonin
Serotonin Agents